CRI Researcher Awarded $1.35 Million Grant to Pursue Liver Cancer Therapy

Nov. 24, 2014 — Dr. Hao Zhu, an Assistant Professor at the Children’s Medical Center Research Institute at UT Southwestern, has been awarded a $1.35 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) for research related to the development of effective therapies for chronic liver disease and liver cancer.

Liver cancer, which is almost always preceded by cirrhosis, is a significant cause of cancer-related death worldwide. In the United States, Texas has the second highest incidence rate of liver cancer.

“We recently identified a genetic pathway known as the SWI/SNF chromatin-remodeling pathway that when suppressed, results in better liver regeneration and the potential for preventing liver cancer,” said Dr. Zhu, who is also a CPRIT Scholar in Cancer Research. “With the help of this generous funding support, we will use mouse models to validate the pathway as a target in chronic liver disease and liver cancer, and then work to develop novel compounds for the simultaneous treatment of cirrhosis and cancer in the liver.”