Hao Zhu Laboratory


Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H. 2016. Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell. (PubMed)

Zhou K*, Nguyen LH*, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ. *Equal contributors. 2016. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. PNAS 2016 Jan 4. (PubMed)

Wen X, Reynolds L, Mulik RS, Kim SY, Van Treuren T, Nguyen LH, Zhu H, Corbin IR. 2015. Hepatic arterial infusion of low-density lipoprotein docosahexaenoic acid nanoparticles selectively disrupts redox balance in hepatoma cells and reduces growth of orthotopic liver tumors in rats. Gastroenterology 2015 Oct 17. (PubMed)

Wu L*, Nguyen LH*, Zhou K, Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, and Zhu H. *Equal contributors. 2015. Precise Let-7 expression levels balance organ regeneration against tumor suppression. eLife. (10.7554/eLife.09431)

Nguyen LH*, Robinton DA*, Seligson MT*, Wu L, Li L, Rakheja D,  Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ** and Zhu H**. *Equal contributors. **Co-corresponding authors. 2014. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell Aug 11;26(2):248-61. (PubMed)

Zhang S*, Li L*, Kendrick SL, Gerard RD and Zhu H. *Equal contributors. 2014. TALEN mediated somatic mutagenesis in murine models of cancer. Cancer Research Jul 28. pii: canres.0529.2014. (PubMed)

Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ. 2014. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes and Development May 1;28(9):971-82. (PubMed)

Shyh-Chang N*, Zhu H*, de Soysa NT, Shinoda G, Seligson MT, Tsanov K, Nguyen L, Asara JM, Cantley LC and Daley GQ. *Equal contributors. 2013. Lin28 enhances tissue repair by reprogramming bioenergetic metabolism. Cell 155(4):778-92. (PubMed)

Nishino J, Kim S, Zhu Y, Zhu H, and Morrison SJ. 2013. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. eLife 2:e00924. (PubMed)

Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. 2013. Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation. Science 339(6116):222-6. (PubMed)

Zhu H*, Shyh-Chang N*, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. *Equal contributors. 2011. The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell 147(1):81-94. (PubMed)

Zhu H, Lensch MW, Cahan P, Daley GQ. 2011. Investigating monogenic and complex diseases with pluripotent stem cells. Nature Reviews Genetics 12(4):266-75. (PubMed)

Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ. 2011. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470(7332):95-100. (PubMed)

Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ. 2010. Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics 42(7):626-30. (PubMed)

West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, Sero JE, Zhu H, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ. 2009. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460(7257):909-13. (PubMed)