Jian Xu Laboratory


Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH*, and Xu J*. (2016) Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis. Developmental Cell, 36(1):9-23. (*corresponding author). (PubMed)

Xu J*, Shao Z*, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, and Orkin SH. Developmental control of Polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell 2015, 57(2):304-316. (*co-first author). (PubMed)

Pinello L*, Xu J*, Orkin SH, and Yuan GC. Analysis of chromatin state plasticity identifies cell-type specific regulators of H3K27me3 patterns. Proc. Natl. Acad. Sci. USA 2014, 111(3):E344-53. (*co-first author) (Pub Med)

Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, and Orkin SH. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell 2014, 14:68-80. (PubMed)

Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, Stamatoyannopoulos JA, Lettre G, and Orkin SH. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 2013, 342:253-257. (PubMed)

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, and Orkin SH. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc. Natl. Acad. Sci. USA 2013, 110:6518-23. (PubMed)

Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, and Orkin SH. Mapping cellular hierarchy by single cell analysis of the cell surface repertoire. Cell Stem Cell 2013, 12(4):492-505. (PubMed)

Xu J, Smale ST. Designing an enhancer landscape. Cell 2012, 151(5):929-931. (PubMed)

Xu J*, Shao Z*, Glass K, Bauer DE, Pinello L, Handel BV, Hou S, Stamatoyannopoulos JA, Mikkola HKA, Yuan GC, Orkin SH. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental Cell 2012, 23(4):796-811. (*co-first author) (PubMed)

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 2011, 334(6058):993-996. (PubMed)

Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. New England Journal of Medicine 2011, 365:807-814. (PubMed)

Sankaran VG*, Xu J*, Orkin SH. Advances in the understanding of haemoglobin switching. British Journal of Haematology 2010, 149(2):181-194. Review. (*equal contribution). (PubMed)

Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of g-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development 2010, 24(8):783-798. (PubMed)

Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, and Smale ST. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes & Development 2009, 23(24):2824-2838. (PubMed)

Sankaran VG*, Xu J*, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature 2009, 460: 1093-1097. (*co-first author) (PubMed)

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Handel BV, Mikkola HKA, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the development stage-specific repressor BCL11A. Science 2008, 322: 1839-1842. (PubMed)

Xu J, Pope SD, Jazirehi AR, Attema JL, Papathanasiou P, Watts JA, Zaret KS, Weissman IL, and Smale ST. Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc. Natl. Acad. Sci. USA 2007, 104: 12377-12382. (PubMed)

Zhou L, Nazarian AA, Xu J, Tantin D, Corcoran LM, and Smale ST. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol. Cell. Biol. 2007, 27: 2698-2712. (PubMed)

Guo JY*, Xu J*, Mao DQ, Fu LL, Gu JR, and Zhu JD. The promoter analysis of the human C17orf25 gene, a novel 17p13.3 gene. Cell Res 2002, 12(5-6): 339-352. (*co-first author) (PubMed)

Xu J, Zhu JD, Ni M, Wan DF, and Gu JR. The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1 (RNMTL1) gene, a newly discovered 17p13.3 gene. Cell Res 2002, 12(3-4): 177-197. (PubMed)