In the News
March 9, 2014 — For the first time, researchers have shown that an essential biological process known as protein synthesis can be studied in adult stem cells, something scientists have long struggled to accomplish. The groundbreaking findings from the Children’s Medical Center Research Institute at UT Southwestern (CRI) also demonstrate that the precise amount of protein produced by blood-forming stem cells is crucial to their function.
March 4, 2014 — Sean Morrison, Ph.D., Director of the Children’s Research Institute, recently delivered a President’s Lecture Series presentation, Understanding Cancer Through the Lens of Stem Cell Biology, on the campus of UT Southwestern. Afterward, he expanded on his remarks during a discussion on stem cells and aging. Read an excerpt of his comments.
Jan. 22, 2014 — Scientists have known for years that stem cells in male and female sexual organs are regulated differently by their respective hormones. In a surprising discovery, researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) and Baylor College of Medicine have found that stem cells in the blood-forming system — which is similar in both sexes — also are regulated differently by hormones, with estrogen proving to be an especially prolific promoter of stem cell self-renewal.
Jan. 15, 2014 — The potential for understanding how the biological setting that sustains blood-forming stem cells is involved in normal and disease physiology promises new approaches to treating blood disorders. Defining niche components and how they work together to regulate blood formation provides the opportunity to not only improve regeneration following injury or blood-forming stem cell transplantation, but also to understand how disordered niche function could contribute to disease.
Sean Morrison, Ph.D., Director of the Children’s Research Institute at UT Southwestern (CRI), has co-authored an evaluation of research on the blood-forming stem cell niche in bone marrow — the primary environment for the cells’ maintenance and self-renewal — bringing past discoveries into context and looking ahead to questions that still need to be addressed. Read the research review published in Nature.
Nov. 27, 2013 — Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI), the University of California at San Francisco and the University of Michigan have solved a mystery that has stumped scientists for years, discovering how leukemia-causing mutations enable pre-leukemic stem cells to outperform their healthy counterparts.
Nov. 7, 2013 — Two groups of scientists at the Children’s Medical Center Research Institute at UT Southwestern have made complementary discoveries that break new ground on efforts to turn back the body’s clock on cellular activity, paving the way for a better understanding of stem cells, tissue growth and regeneration.
Oct. 24, 2013 — A group of researchers including Ralph DeBerardinis, M.D., Ph.D., Director of the Genetic and Metabolic Disease Program at the Children’s Research Institute at UT Southwestern, have identified new therapeutic targets for a significant percentage of patients who have the most common form of lung cancer among smokers, non-smokers and people under age 45. The targets were detected in spite of the myriad difficulties posed by genetically complex tumor lesions that have hindered efforts to identify therapeutic opportunities. Read the research published in Cell.
Sept. 23, 2013 — Children’s Medical Center Research Institute at UT Southwestern has recruited a new faculty member, Woo-Ping Ge, Ph.D. His laboratory will research the interactions between brain vasculature and the nervous system, in hopes of developing therapeutic targets for treating diseases such as stroke and brain tumors. Dr. Ge recently shared his thoughts about joining the CRI team and the impact he expects his new surroundings will have on his work. Read the Q&A interview.
Sept. 19, 2013 — Previously published research has suggested that the properties of cancer stem cells can explain a variety of unsolved clinical problems. However, new experimental approaches have provided additional perspective and insight regarding the extent to which metastasis, therapy resistance and disease progression reflect the intrinsic properties of cancer stem cells as opposed to genetic evolution or other sources of variation in cancer cell properties.
Sean Morrison, Ph.D., Director of the Children’s Research Institute at UT Southwestern (CRI), and Corbin Meacham, Ph.D., an American Cancer Society Fellow at CRI, have evaluated the implications of new data for the cancer stem-cell model and the degree to which the model accounts for clinically important aspects of disease progression, like therapy resistance and metastatic dissemination. Read their research review published in Nature.
Sept. 3, 2013 — Glutamine is an abundant and highly versatile nutrient whose metabolism has implications for tumor cell biology, making it an appealing target for new clinical strategies to detect, monitor and treat cancer. Ralph DeBerardinis, M.D., Ph.D., Director of the Genetic and Metabolic Disease Program at the Children’s Research Institute at UT Southwestern (CRI); Ajla Wasti, M.D., a clinical fellow at CRI; and Chris Hensley, an M.D./Ph.D. student at CRI, have evaluated the metabolic functions of glutamine and its involvement in supporting tumor malignancy, in an effort to better understand how the information could be used in clinical oncology. Read their research review published in The Journal of Clinical Investigation.