Ralph DeBerardinis Laboratory


DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S and Thompson CB. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. PNAS USA 104:19345-19350 (2007). (PubMed)

Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES and DeBerardinis RJ. Pyruvate carboxylase catalyzes an alternative metabolic strategy allowing tumor cells to escape glutamine dependence. PNAS USA 108: 8674-8679 (2011). (PubMed)

Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby, L, Micaroni M, Chaneton B, Hedley A, Kalna G, Pollard PJ, Tomlinson IPM, Watson, DG, DeBerardinis RJ, Shlomi T, Ruppin E and Gottlieb E.  Haem oxygenase is synthetically lethal with the mitochondrial tumor suppressor fumarate hydratase. Nature 477: 225-228 (2011). (PubMed)

Mullen AR, Wheaton WW, Jin ES, Chen P-S, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS and DeBerardinis RJ.  Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481:385-388 (2011). (PubMed)

Choi C, Ganji SK, DeBerardinis RJ, Hatanpaa KJ, Rakheja D, Kovacs Z, Yang X-L, Mashimo T, Raisanen JM, Marin-Valencia I, Pascual JM, Madden CJ, Mickey BE, Malloy CR, Bachoo R and Maher EA. Noninvasive detection of 2-hydroxyglutarate by magnetic resonance spectroscopy in patients with IDH-mutated malignant gliomas. Nat Med 18: 624-629 (2012). (PubMed)

Marin-Valencia I, Cho S, Yang C, Mashimo T, Yang X-L, Rajagopalan KN, Vemireddy V, Cai L, Good L, Tu BP, Hatanpaa K, Mickey BE, Pascual JM, Maher EA, Malloy CR, *DeBerardinis RJ and *Bachoo RM. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo. Cell Metab 15: 827-837 (2012). (PubMed)

Wauson EM, Zaganjor E, Lee A-Y, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, DeBerardinis RJ and Cobb MH.  The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Molecular Cell 47: 1-12 (2012). (PubMed)

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Choi C, Jeffrey FM, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR and DeBerardinis RJ. Metabolism of [U-13C]glucose in Human Brain Tumors In Vivo. NMR in Biomedicine 25: 1234-1244 (2012). (PubMed)

Hitosugi T, Zhou L, Elf S, Fan J, Kang H-B, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu T-L, Jin P, Aleckovic M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Chen J et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis by controlling intracellular levels of 3-phosphoglycerate and 2-phosphoglycerate. Cancer Cell 22:585-600 (2012). (PubMed)

Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS and DeBerardinis RJ. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Reports pii: S2211-1247(14)00339-8 (2014). (PubMed)

Reviews on Metabolism

DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB.  The biology of cancer: metabolic reprogramming that fuels growth and proliferation. Cell Metab 7:11-20 (2008). (PubMed)

DeBerardinis RJ, Sayed N, Ditsworth D and Thompson CB.  Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 18:54-61 (2008). (PubMed)

DeBerardinis RJ and Cheng T.  Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29:313-324 (2010). (PubMed)

DeBerardinis RJ and Thompson CB.  Metabolism and disease: what metabolic outliers teach us about biology and pathology. Cell 148: 1132-1144 (2012). (PubMed)