Selected Zhu Lab Publications

2017

Celen, C., Chuang, J.C., Luo, X., Nijem, N., Walker, A.K., Chen, F., Zhang, S., Chung, A.S., Nguyen, L.H., Nassour, I., Budhipramono, A., Sun, X., Bok, L.A., McEntagart, M., Gevers, E.F., Birnbaum, S.G., Eisch, A.J., Powell, C.M., Ge, W.P., Santen, G.W., Chahrour, M., and Zhu, H. (2017). Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. Elife. e25730. (PubMed)

2016

Sun, X., Chuang, J.C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L.H., Wang, S.C., Signer, R.A., Sorouri, M., Nassour, I., Liu, X., Xu, J., Wu, M., Zhao, Y., Kuo, Y.C., Wang, Z., Xing, C., and Zhu, H. (2016). Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell 18, 456–466. (PubMed)

Zhou, K.*, Nguyen, L.H.*, Miller, J.B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J.T., Zhu, H., and Siegwart, D.J. (2016). Modular degradable dendrimers enable small RNAs to extend survival in an aggressiveliver cancer model. Proc. Natl. Acad. Sci. U S A 113, 520–525. (PubMed) *Equal contributors

2015

Wen, X., Reynolds, L., Mulik, R.S., Kim, S.Y., Van Treuren, T., Nguyen, L.H., Zhu, H., and Corbin, I.R. (2016). Hepatic arterial infusion of low-density lipoprotein docosahexaenoic acid nanoparticles selectively disrupts redox balance in hepatoma cells and reduces growth of orthotopic liver tumors in rats. Gastroenterology 150, 488–498. (PubMed)

Wu, L.*, Nguyen, L.H.*, Zhou, K., Soysa, T.Y., Li, L., Miller, J.B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M.T., Zeitels, L.R., Acharya, A., Wang, S.C., Mendell, J.T., He, X., Nishino, J., Morrison, S.J., Siegwart, D.J., Daley, G.Q., Shyh-Chang, N., and Zhu, H. (2015). Precise Let-7 expression levels balance organ regeneration against tumor suppression. eLife. 4:e09431. (PubMed) *Equal contributors

2014

Nguyen, L.H.*, Robinton, D.A.*, Seligson, M.T.*, Wu, L., Li, L., Rakheja, D., Comerford, S.A., Ramezani, S., Sun, X., Parikh, M.S., Yang, E.H., Powers, J.T., Shinoda, G., Shah, S.P., Hammer, R.E., Daley, G.Q.,** and Zhu, H.**. * (2014). Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell 26, 248–261. (PubMed) Equal contributors **Co-corresponding authors

Zhang, S.*, Li, L.*, Kendrick, S.L., Gerard, R.D., and Zhu, H.  (2014). TALEN mediated somatic mutagenesis in murine models of cancer. Cancer Res 74, 5311-5321. (PubMed) *Equal contributors

Urbach, A., Yermalovich, A., Zhang, J., Spina, C.S., Zhu, H., Perez-Atayde, A.R., Shukrun, R., Charlton, J., Sebire, N., Mifsud, W., Dekel, B., Pritchard-Jones, K., and Daley, G.Q. (2014). Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 28, 971–982. (PubMed)

2013

Shyh-Chang, N.*, Zhu, H.*, de Soysa, N.T., Shinoda, G., Seligson, M.T., Tsanov, K., Nguyen, L., Asara, J.M., Cantley, L.C. and Daley, G.Q. (2013). Lin28 enhances tissue repair by reprogramming bioenergetic metabolism. Cell 155, 778–792. (PubMed) *Equal contributors

Nishino, J., Kim, S., Zhu, Y., Zhu, H., and Morrison, S.J. (2013). A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. eLife 2:e00924. (PubMed)

Shyh-Chang, N., Locasale, J.W., Lyssiotis, C.A., Zheng, Y., Teo, R.Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J.J., Zhu, H., Asara, J.M., Daley, G.Q., and Cantley, L.C. (2013). Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation. Science 339, 222–226. (PubMed)

2011

Zhu, H.*, Shyh-Chang, N.*, et al.  (2011). The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell 147, 81–94. (PubMed) *Equal contributors

Zhu, H., Lensch, M.W., Cahan, P., Daley, G.Q. (2011). Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. Genet 12, 266–275. (PubMed)

Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., et al. (2011). Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470, 95–100. (PubMed)

2010

Zhu, H., et al. (2010). Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat. Genet 42, 626–630. (PubMed)

2009

West, J.A., Viswanathan, S.R., Yabuuchi, A., Cunniff, K., Takeuchi, A., Park, I.H., Sero, J.E., Zhu, H., et al. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460, 909–913. (PubMed)


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