Sean Morrison Laboratory, the Hamon Laboratory for Stem Cell and Cancer Biology


Buszczak, M., R.A.J. Signer, S.J. Morrison. 2014. Cellular differences in protein synthesis regulate tissue homeostasis. Cell (PubMed)

Zhou, B.O., R. Yue, M. M. Murphy, J.G. Peyer, S.J. Morrison. 2014. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15:154-168. (PubMed)

Mich, J.K., R.A.J. Signer, D. Nakada, A. Pineda, R.J. Burgess, T.Y. Vue, J.E. Johnson, S.J. Morrison. 2014. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. eLife 10.7554/eLife. (PubMed)

Signer, R.A.J., J.A. Magee, A. Salic, S.J. Morrison. 2014. Haematopoietic stem cells require a highly regulate protein synthesis rate. Nature 509:49-54. (PubMed)

Nakada, D., H. Oguro, B. Levi, N. Ryan, A. Kitano, Y. Saitoh, M. Takeichi, G. Wendt, and S.J. Morrison. 2014. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature 505:555-558. (PubMed)

Morrison, S.J., and D.T. Scadden. 2014. The bone marrow niche for haematopoietic stem cells. Nature 505:327-334. (PubMed)

Li, Q., N. Bohin, T. Wen, V. Ng, J. Magee, S.C. Chen, K. Shannon, and S.J. Morrison. 2013. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature 504:143-147. (PubMed)

Meacham, C.E. and S.J. Morrison. 2013. Tumor heterogeneity and cancer cell plasticity. Nature 501:328-337. (PubMed)

Ding, L. and S.J. Morrison. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495:231-235. (PubMed)

Signer, R.A. and S.J. Morrison. 2013. Mechanisms that regulate stem cell aging and life span. Cell Stem Cell 12:152-65. (PubMed)

Ding, L., T.L. Saunders, G. Enikolopov, and S.J. Morrison. 2012. Endothelial and perivascular cells maintain hematopoietic stem cells. Nature 481:457-462. (PubMed)

Quintana, E., E. Piskounova, M. Shackleton, D. Weinberg, U. Eskiocak, D.R. Fullen, T.M., and S.J. Morrison. 2012. Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Science Translational Medicine 4(159):159ra149. (PubMed)

Nakada, D., T.L. Saunders and S.J. Morrison. 2010. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468:653-658. (PubMed)

Chuikov, S., B.P. Levi, M.L. Smith and S.J. Morrison. 2010. Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nature Cell Biology 12: 999-1006. (PubMed)

Shackleton, M., E. Quintana, E. Fearon and S.J. Morrison. 2009. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138: 822-829. (PubMed)

Quintana, E., M. Shackleton, M. Sabel, D.Fullen, T.M. Johnson, and S.J. Morrison. 2008. Efficient tumor formation by single human melanoma cells. Nature 456:593-598. (PubMed)

Nishino, J., I. Kim, K. Chada and S.J. Morrison. 2008. Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16 Ink4a and p19Arf expression.
Cell 135: 227-239. (PubMed)

Morrison, S.J. and A. Spradling. 2008. Stem Cells and Niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132: 598-611. (PubMed)

Kiel M.J., S. He, R. Ashkenazi, S.N. Gentry, M. Teta, J.A. Kushner, T. L. Jackson and S.J. Morrison. 2007. Hematopoietic stem cells do not asymmetrically segregate chromosomes or retain bromodeoxyuridine. Nature 449: 238-242. (PubMed)

Kim, I., T.L. Saunders and S.J. Morrison. 2007. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130: 470-483. (PubMed)

Molofsky, A.V., S.G. Slutsky, N.M. Joseph, S. He, R. Pardal, J. Krishnamurthy, N. Sharpless and S.J. Morrison. 2006. Increasing p16 Ink4a expression decreases forebrain progenitor function and neurogenesis during ageing. Nature 443: 448-452. (PubMed)

Morrison, S.J. and J. Kimble. 2006. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441: 1068-1074. (PubMed)

Yilmaz, O.H., R. Valdez, B. Theisen, W. Guo, D. Ferguson, H. Wu and S.J. Morrison. 2006. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initating cells. Nature 441: 475-482. (PubMed)

Kiel, M.J., O.H. Yilmaz, T. Iwashita, C. Terhorst, and S.J. Morrison. 2005. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121: 1109-1121. (PubMed)

Molofsky, A.V., R. Pardal, T. Iwashita, I.K. Park, M.F. Clarke, and S.J. Morrison. 2003. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962-967. (PubMed)