Sean Morrison Receives Individual Investigator Award from the Cancer Prevention and Research Institute of Texas (CPRIT)
Dr. Sean Morrison, Professor of Pediatrics and Director of the Children’s Medical Center Research Institute at UT Southwestern, received an Individual Investigator Award from CPRIT to study the mechanisms of melanoma metastasis. Dr. Morrison is one of five researchers at UT Southwestern to receive funding from CPRIT.
Dr. Morrison aims to better understand the complex molecular mechanisms that allow cancer cells to spread. This research will build on earlier work that found metastasis of human melanoma cells to be limited by oxidative stress, caused by the generation inside cancer cells of highly toxic reactive molecules known as reactive oxygen species. Most melanoma cells that enter the blood die from oxidative stress. Dr. Morrison believes the rare melanoma cells that survive during metastasis undergo specific metabolic adaptations that allow them to withstand the oxidative stress.
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