August 19, 2020 Lymph nodes found to protect cancer cells from oxidative stress. Melanoma cells discovered to take up anti-oxidants..Read More
Metabolic differences between melanomas, and even among cells within the same melanoma, confer differences in metastatic potential that may determine which melanomas are able to progress to late stage disease. Melanoma cells that take up more lactate increase their production of antioxidants which helps them survive in the blood and spread more efficiently. This discovery could be used to develop new therapies that reduce the proportion of patients who progress to late stage disease.
December 18, 2019 Metabolic differences among melanoma cells confer differences in metastatic potential. This discovery could be used to develop..Read More
April 30, 2019 Integration of genomic and metabolomic data to identify inborn errors of metabolism in patients, potentially opening a..Read More
April 4, 2019 Genetic mutations that accumulate in the adult liver as a result of chronic liver damage found to..Read More
May 23, 2018 Ralph DeBerardinis, M.D., Ph.D. selected as a Howard Hughes Medical Institute (HHMI) Investigator.
The liver has an unusual amount of polyploid cells which have multiple extra copies of each gene. These cells are less likely than normal cells to transform into cancer cells after chronic liver damage. These findings address a long-standing mystery in liver biology by suggesting that polyploidy suppresses the development of cancer.
February 8, 2018 The liver has an unusual amount of polyploid cells which have multiple extra copies of each gene…Read More
October 15, 2017 Lactate, long considered a waste product of cancer cells, discovered to fuel growing tumors. These findings represent..Read More
August 24, 2017 A new high-throughput method developed to study regions of DNA that control which genes are turned on..Read More