Timeline Stories Archives | Children's Research Institute

August 5, 2020

Katie Regan

Lymph nodes found to protect cancer cells from oxidative stress. Melanoma cells were found to take up anti-oxidants when passing through the lymph nodes, which prevents ferroptosis in the blood. This explain why many cancers metastasize to lymph nodes before forming distant tumors.

August 19, 2020 Lymph nodes found to protect cancer cells from oxidative stress. Melanoma cells discovered to take up anti-oxidants..Read More

July 28, 2020

Katie Regan

Metabolic differences between melanomas, and even among cells within the same melanoma, confer differences in metastatic potential that may determine which melanomas are able to progress to late stage disease. Melanoma cells that take up more lactate increase their production of antioxidants which helps them survive in the blood and spread more efficiently. This discovery could be used to develop new therapies that reduce the proportion of patients who progress to late stage disease.

December 18, 2019 Metabolic differences among melanoma cells confer differences in metastatic potential. This discovery could be used to develop..Read More

July 27, 2020

Katie Regan

Sean Morrison, Ph.D., elected to the National Academy of Science (NAS).

April 27, 2020 Sean Morrison, Ph.D., elected to the National Academy of Science.

July 27, 2020

Katie Regan

Integration of genomic and metabolomic data to identify inborn errors of metabolism in patients, potentially opening a new approach to diagnosing pediatric metabolic diseases.

April 30, 2019 Integration of genomic and metabolomic data to identify inborn errors of metabolism in patients, potentially opening a..Read More

July 27, 2020

Katie Regan

Genetic mutations that accumulate in the adult liver as a result of chronic liver damage found to promote tissue regeneration without necessarily promoting liver cancer. This raises the possibility of identifying therapeutic strategies that promote liver regeneration without increasing cancer risk.

April 4, 2019 Genetic mutations that accumulate in the adult liver as a result of chronic liver damage found to..Read More

July 27, 2020

Katie Regan

Sean Morrison, Ph.D., elected to the National Academy of Medicine (NAM).

October 15, 2018 Sean Morrison, Ph.D., elected to the National Academy of Medicine.

July 27, 2020

Katie Regan

Ralph DeBerardinis, M.D., Ph.D. selected as a Howard Hughes Medical Institute (HHMI) Investigator.

May 23, 2018 Ralph DeBerardinis, M.D., Ph.D. selected as a Howard Hughes Medical Institute (HHMI) Investigator.

July 27, 2020

Katie Regan

The liver has an unusual amount of polyploid cells which have multiple extra copies of each gene. These cells are less likely than normal cells to transform into cancer cells after chronic liver damage. These findings address a long-standing mystery in liver biology by suggesting that polyploidy suppresses the development of cancer.

February 8, 2018 The liver has an unusual amount of polyploid cells which have multiple extra copies of each gene…Read More

July 27, 2020

Katie Regan

Lactate, long considered a waste product of cancer cells, discovered to fuel growing tumors. These findings represent a major shift in how researchers view lung cancer metabolism. They represent a new path of study for therapies and imaging techniques.

October 15, 2017 Lactate, long considered a waste product of cancer cells, discovered to fuel growing tumors. These findings represent..Read More

July 27, 2020

Katie Regan

A new high-throughput method developed to study regions of DNA that control which genes are turned on and off in cells. This method will allow researchers to better understand how genes become dysregulated in cancer and other diseases.

August 24, 2017 A new high-throughput method developed to study regions of DNA that control which genes are turned on..Read More

Lymph nodes found to protect cancer cells from oxidative stress. Melanoma cells were found to take up anti-oxidants when passing through the lymph nodes, which prevents ferroptosis in the blood. This explain why many cancers metastasize to lymph nodes before forming distant tumors.

Sean Morrison, Ph.D., elected to the National Academy of Science (NAS).

Integration of genomic and metabolomic data to identify inborn errors of metabolism in patients, potentially opening a new approach to diagnosing pediatric metabolic diseases.

Genetic mutations that accumulate in the adult liver as a result of chronic liver damage found to promote tissue regeneration without necessarily promoting liver cancer. This raises the possibility of identifying therapeutic strategies that promote liver regeneration without increasing cancer risk.

Sean Morrison, Ph.D., elected to the National Academy of Medicine (NAM).

Ralph DeBerardinis, M.D., Ph.D. selected as a Howard Hughes Medical Institute (HHMI) Investigator.

Lactate, long considered a waste product of cancer cells, discovered to fuel growing tumors. These findings represent a major shift in how researchers view lung cancer metabolism. They represent a new path of study for therapies and imaging techniques.

A new high-throughput method developed to study regions of DNA that control which genes are turned on and off in cells. This method will allow researchers to better understand how genes become dysregulated in cancer and other diseases.

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