Selected DeBerardinis Lab Publications


Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y-F., Ni, M., Huffman, K.E., Girard, L., Byers, L.A., Unsal-Kacmaz, K., Peña, C.G., Heymach, J.V., Wauters, E., Vansteenkiste, J., Castrillon, D.H., Chen, B.P.C., Wistuba, I,, Lambrechts, D., Xu, J., Minna, J.D., and DeBerardinis, R.J. (2017). CPS1 maintains pyrimidine pools and DNA synthesis is KRAS/LKB1-mutant lung cancer cells.  Nature 546, 168-172. (PubMed)

Faubert, B., and DeBerardinis, R.J. (2017). Analyzing tumor metabolism in vivo. Ann Rev Cancer Biol 1, 99-117.

Vander Heiden, M.G., and DeBerardinis, R.J. (2017). Understanding the intersections between metabolism and cancer biology. Cell 168, 657-699. (PubMed)


Hensley, C.T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., et al. (2016). Metabolic heterogeneity in human lung tumors. Cell 164, 681–694. (PubMed)

Jiang, L., Shestov, A.A., Swain, P., Yang, C., Parker, S.J., Wang, Q.A., Terada, L.S., Adams, N.D., McCabe, M.T., Pietrak, B., et al. (2016). Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature 532, 255–258. (PubMed)

DeBerardinis, R.J., and Chandel, N.S. (2016). Fundamentals of cancer metabolism. Sci. Adv 2:e1600200. (PubMed)


Boroughs, L.K., and DeBerardinis, R.J. (2015). Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol 17, 351–359. (PubMed)

Rajagopalan. K.N., Egnatchik, R.A., Calvaruso, M.A., Wasti, A.T., Padanad, M.S., Boroughs, L.K., Ko, B., Hensley, C.T., Acar, M., Hu, Z., Jiang, L., Pascual, J.M., Scaglioni, P.P., and DeBerardinis, R.J. (2015). Metabolic plasticity maintains proliferation in pyruvate dehydrogenase-deficient cells. Cancer Metab. 3:7. (PubMed)

Piskounova, E., Agathocleous, M., Hu, Z., Mann, S.E., Zhao, Z., Leitch, A.M., Johnson, T.M., DeBerardinis, R.J., and Morrison, S.J. (2015). Reversible metabolic changes in human melanoma cells enable distant metastasis. Nature 527, 186-191. 


Mullen, A.R., Hu, Z., Shi, X., Jiang, L., Boroughs, L.K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L.B., Linehan, W.M., et al. (2014). Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep 7, 169-1690. (PubMed)

Yang, C., Ko, B., Hensley, C.T., Jiang, L., Wasti, A.T., Kim, J., Sudderth, J., Calvaruso, M.A., Lumata, L., Mitsche, et al. (2014). Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol. Cell 56, 414–424. (PubMed)


Hamanaka, R.B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen ,A.R., Getsios, S., Gottardi, C.J., DeBerardinis, R.J., Lavker, R.M., and Chandel, N.S. (2013). Mitochondrial ROS regulate epidermal differentiation and hair follicle development. Sci. Signal. 6, 261 (PubMed)

Kim, H., Pecot, C.V., Kim, J., Larsen, J.E., Mendiratta, S., Seo, B.Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Zubovych, I., Wu, S., DeBrabander, J., Komurov, K., Posner, B.A., Brekken, R., Sood, A.K., DeBerardinis, R.J., Roth, M.G., Minna, J.D., and White, M.A.  (2013). Systematic Identification of Molecular Subtype-selective Vulnerabilities in Non-Small Cell Lung Cancer.  Cell 155, 552-566. (PubMed)


DeBerardinis, R.J., and Thompson, C.B. (2012). Metabolism and disease: what metabolic outliers teach us about biology and pathology. Cell 148, 1132–1144. (PubMed)

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X. L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., et al. (2012). Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo. Cell Metab 15, 827–837. (PubMed)

Choi, C., Ganji, S.K., DeBerardinis, R.J., Hatanpaa, K.J., Rakheja, D., Kovacs, Z., Yang, X-L., Mashimo, T., Raisanen, J.M., et al. (2012). Noninvasive detection of 2-hydroxyglutarate by magnetic resonance spectroscopy in patients with IDH-mutated malignant gliomas.  Nat. Med. 18, 624-629. (PubMed)

Maher, E.A., Marin-Valencia, I., Bachoo, R.M., Mashimo, T., Raisanen, J., Hatanpaa, K.J., Jindal, A., Choi, C., Jeffrey, F.M., Madden, C., Mathews, D., Pascual, J.M., Mickey, B.E., Malloy, C.R., and DeBerardinis, R.J. (2012). Metabolism of [U-13C]glucose in Human Brain Tumors In Vivo. NMR in Biomedicine 25, 1234-1244. (PubMed)


Cheng, T., Sudderth, J., Yang, C., Mullen, A.R., Jin, E.S., Matés, J.M., and DeBerardinis, R.J. (2011). Pyruvate carboxylase catalyzes an alternative metabolic strategy allowing tumor cells to escape glutamine dependence. Proc. Natl. Acad. Sci. U. S. A 108, 8674–8679 (PubMed)

Mullen, A.R., Wheaton, W.W., Jin, E.S., Chen, P.H., Sullivan, L.B., Cheng, T., Yang, Y., Linehan, W.M., Chandel, N.S., and DeBerardinis, R.J. (2011). Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385–388. (PubMed)


Yang, C., Sudderth, J., Dang, T., Bachoo, R.G., McDonald, J.G., and DeBerardinis, R.J. (2009). Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.  Cancer Res. 69, 7986-7993. (PubMed)


DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., and Thompson, C.B. (2008).  The biology of cancer: metabolic reprogramming that fuels growth and proliferation.  Cell Metab. 7,11-20. (PubMed)


DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., and Thompson, C.B. (2007). Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U. S. A 104, 19345–19350. (PubMed)