Metabolism of Lymphoid and Myeloid Leukemia
Cancer metabolism is determined by driver mutations, the environment, and the tissue of origin. Cancers arise from particular cell types within a tissue, and we hypothesize that cancer metabolism is also determined by the metabolism of the stem or progenitor cell of origin. Our previous observations on the cell type specificity of metabolism raise the question of whether leukemias that arise from different cell types are metabolically distinct from each other. We have identified a metabolic pathway that is required in only one hematopoietic cell type, but not others, and in the leukemia that arises from that cell type. We are pursuing these findings to understand the mechanistic connection between cell type and metabolism and to target this pathway therapeutically in leukemia.