The Role of Mechanotransduction in Blood Disorders

By December 13, 2022

The Role of Mechanotransduction in Blood Disorders

Rare mutations in PIEZO1 mechanically activated ion channels cause hereditary xerocytosis, a disorder characterized by red blood cell dehydration. Recently, comprehensive medical exams of xerocytosis patients identified other perplexing syndromes associated with PIEZO1 variants. We hypothesize that PIEZO1-dependent mechanotransduction could play important roles in various blood cell lineages, beyond its normal functions in erythrocytes. We use humanized mouse models to uncover the molecular basis of these disorders.

CONTACT
6000 Harry Hines Blvd.
Dallas, TX 75235
CONNECT

                   

NEWSLETTER