Most cancer deaths are caused by metastasis – the spread of cancer cells beyond the original tumor to other parts of the body. Metastasis is a largely inefficient process in which most cancer cells that enter into the circulation die before they are able to seed and grow in distant organs. It is not well known why only certain cancer cells survive this process. Understanding the molecular adaptions cells must undergo to survive metastasis is essential for finding new therapies.
Using tumor cells isolated directly from patients, I am investigating the molecular mechanisms melanoma cells use to drive growth and metastasis. Melanoma is an aggressive and drug-resistant form of skin cancer with limited treatment options. In particular, I am interested in understanding how melanoma cells adapt metabolically to survive barriers to metastasis, such as oxidative stress.
About Dr. Aurora
Arin B. Aurora earned her bachelor’s degree in biology from Cornell University, followed by a Ph.D. from the University of California, San Francisco. She performed postdoctoral work at Northwestern University Feinberg School of Medicine, earning an American Cancer Society Postdoctoral Fellowship. Dr. Aurora continued her postdoctoral work with Dr. Eric Olson at UT Southwestern, where she made important discoveries toward understanding molecular pathways regulating cardiovascular disease and the connections between the immune system and the capacity of the mammalian heart to regenerate. Based on the strength of her work, Dr. Aurora was awarded an American Heart Association Beginning Grant-in-Aid award.
In 2014, Dr. Aurora joined the faculty of the Children’s Medical Research Institute at UT Southwestern as an assistant professor.
Aurora, A.B., Olson, E.N. (2014). Immune Modulation of Stem Cells and Regeneration. Cell Stem Cell 15,14-25. (PubMed)
Aurora, A.B., Porrello, E.R., Tan, W., Mahmoud, A.I., Hill, J.A., Bassel-Duby, R., Sadek, H.A., and Olson, E.N. (2014). Macrophages are required for neonatal heart regeneration. J. Clinical Investigation 124,1382-1392. (PubMed)
Aurora, A.B., Mahmoud, A.I., Luo, X., Johnson, B.A., van Rooij, E., Matsuzaki, S., Humphries, K.M., Hill, J.A., Sadek, H.A. and Olson ,E.N. (2012). microRNA-214 controls cardiac Ca2+ overload in response to ischemic injury in mice. J. Clinical Investigation 122,1222-1232. (PubMed)
Porrello, E.R., Johnson, B.A., Aurora, A.B., Simpson, E., Nam, Y.J., Matkovich, S.J., Dorn, G.W. 2nd, van Rooij, E., Olson, E.N. (2011). MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res. 109, 670-679. (PubMed)
Aurora, A.B., Biyashev, D., Mirochnik, Y., Zaichuk, T., Renault, M.A., Losordo, D., and Volpert, O.V. NF-B balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement. (2010). Blood 116, 475-484. (PubMed)