Selected Morrison Lab Publications


Tasdogan, A., Faubert, B., Ramesh, V., Ubellacker, J.M., Shen, B., Solmonson, A., Murphy, M.M., Gu, Z., Gu, W., Martin, M., Kasitinon, S.Y., Vandergriff, T., Mathews, T.P., Zhao, Z., Schadendorf, D., DeBerardinis, R.J., and Morrison S.J. (2020). Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature 577, 115-120. (PubMed)


Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G.M., and Morrison, S.J. (2019). Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. eLife, pii: e42274. (PubMed)


Comazzetto, S., Murphy, M.M., Berto, S., Jeffery, E., Zhao, Z., and Morrison, S.J. (2018). Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow. Cell Stem Cell, 24, 477-486. (PubMed)


Agathocleous, M., Meecham, C.E., Burgess, R.J., Piskounova, E., Zhao, Z., Crane, G.M., Cowin, B.L., Bruner, E., Murphy, M.M., Chen, W., Spangrude, G.J., Hu, Z., DeBerardinis, R.J., and Morrison, S.J. (2017). Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature 549, 476-481. (PubMed)


Yue, R., Zhou, B.O., and Morrison, S.J. (2016). Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton. eLife pii:e18782. (PubMed)


Acar, M., Kocherlakota, K.S., Murphy, M.M., Peyer, J.G., Oguro, H., Inra, C.N., Jaiyeola, C.J., Zhao, Z., Luby-Phelps, K., and Morrison, S.J. (2015). Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature 526, 126-130. (PubMed)

Piskounova, E., Agathocleous, M., Murphy, M.M., Hu, Z., Mann, S., Zhao, Z., Leitch, A.M., Johnson, T.M., DeBerardinis, R.J., and Morrison, S.J. (2015). Oxidative stress inhibits distant metastasis by human melanoma cells. Nature 527, 186-191. (PubMed)

Inra, C., Zhou, B.O., Acar, M., Murphy, M.M., Zhao, Z., and Morrison, S.J. (2015). A perisinusoidal niche for extramedullary hematopoiesis in the spleen. Nature 527, 466-471. (PubMed)


Zhou, B.O., Yue, R., Murphy, M.M., Peyer, J.G., and Morrison, S.J. (2014). Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168. (PubMed)

Mich, J.K., Signer, R.A.J., Nakada, D., Pineda, A., Burgess, R.J., Vue, T.Y., Johnson, J.E., and Morrison, S.J. (2014). Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. eLife 3:e02669.(PubMed)

Signer, R.A.J., Magee, J.A., Salic, A., and Morrison, S.J. (2014). Haematopoietic stem cells require a highly regulate protein synthesis rate. Nature 509, 49-54. (PubMed)

Nakada, D., Oguro, H., Levi, B., Ryan, N., Kitano, A., Saitoh, Y., Takeichi, M., Wendt, G., and Morrison, S.J. (2014). Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature 505, 555-558. (PubMed)

Morrison, S.J., and Scadden, D.T. (2014). The bone marrow niche for haematopoietic stem cells. Nature 505, 327-334. (PubMed)


Li, Q., Bohin, N., Wen, T., Ng, V., Magee, J., Chen, S.C., Shannon, K., and Morrison, S.J. (2013). Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature 504, 143-147. (PubMed)

Meacham, C.E., and Morrison, S.J. (2013). Tumor heterogeneity and cancer cell plasticity. Nature 501, 328-337. (PubMed)

Ding, L., and Morrison, S.J. (2013). Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495, 231-235. (PubMed)


Ding, L., Saunders, T.L., Enikolopov, G., and Morrison, S.J. (2012). Endothelial and perivascular cells maintain hematopoietic stem cells. Nature 481, 457-462. (PubMed)

Quintana, E., Piskounova, E., Shackleton, M., Weinberg, D., Eskiocak, U., Fullen, D.R., Johnson, T.M., and Morrison, S.J. (2012). Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med 4, 159ra149. (PubMed)


Nakada, D., Saunders, T.L., and Morrison, S.J. (2010). Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658. (PubMed)

Chuikov, S., Levi, B.P., Smith, M.L., and Morrison, S.J. (2010). Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol 12, 999-1006. (PubMed)


Shackleton, M., Quintana, E., Fearon, E., and Morrison, S.J. (2009). Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138, 822-829. (PubMed)


Quintana, E., Shackleton, M., Sabel, M., Fullen, D., Johnson, T.M., and Morrison, S.J. (2008). Efficient tumor formation by single human melanoma cells. Nature 456, 593-598. (PubMed)

Nishino, J., Kim, I., Chada, K., and Morrison, S.J. (2008). Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16 Ink4a and p19Arf expression. Cell 135, 227-239. (PubMed)

Morrison, S.J., and Spradling, A. (2008). Stem Cells and Niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132, 598-611. (PubMed)


Kiel, M.J., He, S., Ashkenazi, R., Gentry, S.N., Teta, M., Kushner, J.A., Jackson, T.L., and Morrison, S.J. (2007). Hematopoietic stem cells do not asymmetrically segregate chromosomes or retain bromodeoxyuridine. Nature 449, 238-242. (PubMed)

Kim, I., Saunders, T.L., and Morrison, S.J. (2007). Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130, 470-483. (PubMed)


Molofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N., and Morrison, S.J. (2006). Increasing p16 Ink4a expression decreases forebrain progenitor function and neurogenesis during ageing. Nature 443, 448-452. (PubMed)

Morrison, S.J., and Kimble, J. (2006). Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441, 1068-1074. (PubMed)

Yilmaz, O.H., Valdez, R., Theisen, B., Guo, W., Ferguson, D., Wu, H., and Morrison, S.J. (2006). Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482. (PubMed)


Kiel, M.J., Yilmaz, O.H., Iwashita, T., Terhorst, C., and Morrison, S.J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121. (PubMed)


Molofsky, A.V., Pardal, R., Iwashita, T., Park, I.K., Clarke, M.F., and Morrison, S.J. (2003). Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425, 962-967. (PubMed)