Selected DeBerardinis Lab Publications

2020

Faubert, B., Solmonson, A., and DeBerardinis, R.J. (2020). Metabolic reprogramming and cancer progression. Science. 368, eaaw5473. (Full Text)

DeBerardinis, R.J.(2020). Tumor Microenvironment, Metabolism, and Immunotherapy. N Engl J Med.  382, 869-871. (PubMed)

Tasdogan, A., Faubert, B., Ramesh, V., Ubellacker, J.M., Shen, B., Solmonson, A., Murphy, M.M., Gu, Z., Gu, W., Martin, M., Kasitinon, S.Y., Vandergriff, T., Mathews, T.P., Zhao, Z., Schadendorf, D., DeBerardinis, R.J., and Morrison S,J. (2020). Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature 577,115-120. (PubMed)

2019

Chen, P.H., Cai, L., Huffman, K., Yang, C., Kim, J., Faubert, B., Boroughs, L., Ko, B., Sudderth, J., McMillan, E.A., Girard, L., Chen, D., Peyton, M., Shields, M.D., Yao, B., Shames, D.S., Kim, H.S., Timmons, B., Sekine, I., Britt, R., Weber, S., Byers, L.A., Heymach, J.V., Chen, J., White, M.A., Minna, J.D., Xiao, G., and DeBerardinis, R.J. (2019). Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell.76, 838-851. (PubMed)

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L.G., Faubert, B., Vu, H.S., Jiang, L., Ko, B., Morales, N.M., Pei, J., Vale, G., Rakheja, D., Grishin, N.V., McDonald, J.G., Gotway, G.K., McNutt, M.C., Pascual, J.M., and DeBerardinis, R.J. (2019) Functional Assessment of Lipoyltransferase- Deficiency in Cells, Mice, and Humans. Cell Rep. 27, 1376-1386. (PubMed)

2018

Shi, X., Tasdogan, A., Huang, F., Hu, Z., Morrison, S.J., and DeBerardinis, R.J. (2017). The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts. Sci Adv. 3, eaao5268. (PubMed)

Cai, L., Li, Q., Du, Y., Yun, J., Xie, Y., DeBerardinis, R.J., and Xiao, G. (2017). Genomic regression analysis of coordinated expression. Nat Commun. 8, 2187. (PubMed)

Jiang, L., Boufersaoui, A., Yang, C., Ko, B., Rakheja, D., Guevara, G., Hu, Z., and DeBerardinis, R.J. (2017). Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein. Metab Eng. 43, 198-207. (PubMed)

Courtney, K.D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy,V., Funk, A.M., Wimberly, J., McNeil, S.S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J.A., Pedrosa, I., DeBerardinis, R.J., Malloy, C.R., Bachoo, R.M., and Maher, E.A. (2018). Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. Cell Metab. 28, 793-800. (PubMed)

Huang, F., Ni, M., Chalishazar, M.D., Huffman, K.E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L.G., Ireland, A.S., Li, K., Gu, W., Kaushik, A.K., Liu, X., Gazdar, A.F., Oliver, T.G., Minna, J.D., Hu, Z., and DeBerardinis, R.J. (2018). Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab. 28, 369-382. (PubMed)

2017

Faubert, B., Li, K.Y., Cai, L., Hensley, C.T., Kim, J., Zacharias, L.G., Yang, C., Do, Q.N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R.E., Malloy, C.R., Wachsmann, J.W, Young, J.D., Kernstine, K., and DeBerardinis, R.J. (2017) Lactate Metabolism in Human Lung Tumors. Cell 171, 358-371. (PubMed)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y-F., Ni, M., Huffman, K.E., Girard, L., Byers, L.A., Unsal-Kacmaz, K., Peña, C.G., Heymach, J.V., Wauters, E., Vansteenkiste, J., Castrillon, D.H., Chen, B.P.C., Wistuba, I,, Lambrechts, D., Xu, J., Minna, J.D., and DeBerardinis, R.J. (2017). CPS1 maintains pyrimidine pools and DNA synthesis is KRAS/LKB1-mutant lung cancer cells.  Nature 546, 168-172. (PubMed)

Faubert, B., and DeBerardinis, R.J. (2017). Analyzing tumor metabolism in vivo. Ann Rev Cancer Biol 1, 99-117.

Vander Heiden, M.G., and DeBerardinis, R.J. (2017). Understanding the intersections between metabolism and cancer biology. Cell 168, 657-699. (PubMed)

2016

Hensley, C.T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., et al. (2016). Metabolic heterogeneity in human lung tumors. Cell 164, 681–694. (PubMed)

Jiang, L., Shestov, A.A., Swain, P., Yang, C., Parker, S.J., Wang, Q.A., Terada, L.S., Adams, N.D., McCabe, M.T., Pietrak, B., et al. (2016). Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature 532, 255–258. (PubMed)

DeBerardinis, R.J., and Chandel, N.S. (2016). Fundamentals of cancer metabolism. Sci. Adv 2:e1600200. (PubMed)

2015

Boroughs, L.K., and DeBerardinis, R.J. (2015). Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol 17, 351–359. (PubMed)

Rajagopalan. K.N., Egnatchik, R.A., Calvaruso, M.A., Wasti, A.T., Padanad, M.S., Boroughs, L.K., Ko, B., Hensley, C.T., Acar, M., Hu, Z., Jiang, L., Pascual, J.M., Scaglioni, P.P., and DeBerardinis, R.J. (2015). Metabolic plasticity maintains proliferation in pyruvate dehydrogenase-deficient cells. Cancer Metab. 3:7. (PubMed)

Piskounova, E., Agathocleous, M., Hu, Z., Mann, S.E., Zhao, Z., Leitch, A.M., Johnson, T.M., DeBerardinis, R.J., and Morrison, S.J. (2015). Reversible metabolic changes in human melanoma cells enable distant metastasis. Nature 527, 186-191. 

2014

Mullen, A.R., Hu, Z., Shi, X., Jiang, L., Boroughs, L.K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L.B., Linehan, W.M., et al. (2014). Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep 7, 169-1690. (PubMed)

Yang, C., Ko, B., Hensley, C.T., Jiang, L., Wasti, A.T., Kim, J., Sudderth, J., Calvaruso, M.A., Lumata, L., Mitsche, et al. (2014). Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol. Cell 56, 414–424. (PubMed)

2013

Hamanaka, R.B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen ,A.R., Getsios, S., Gottardi, C.J., DeBerardinis, R.J., Lavker, R.M., and Chandel, N.S. (2013). Mitochondrial ROS regulate epidermal differentiation and hair follicle development. Sci. Signal. 6, 261 (PubMed)

Kim, H., Pecot, C.V., Kim, J., Larsen, J.E., Mendiratta, S., Seo, B.Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Zubovych, I., Wu, S., DeBrabander, J., Komurov, K., Posner, B.A., Brekken, R., Sood, A.K., DeBerardinis, R.J., Roth, M.G., Minna, J.D., and White, M.A.  (2013). Systematic Identification of Molecular Subtype-selective Vulnerabilities in Non-Small Cell Lung Cancer.  Cell 155, 552-566. (PubMed)

2012

DeBerardinis, R.J., and Thompson, C.B. (2012). Metabolism and disease: what metabolic outliers teach us about biology and pathology. Cell 148, 1132–1144. (PubMed)

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X. L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., et al. (2012). Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo. Cell Metab 15, 827–837. (PubMed)

Choi, C., Ganji, S.K., DeBerardinis, R.J., Hatanpaa, K.J., Rakheja, D., Kovacs, Z., Yang, X-L., Mashimo, T., Raisanen, J.M., et al. (2012). Noninvasive detection of 2-hydroxyglutarate by magnetic resonance spectroscopy in patients with IDH-mutated malignant gliomas.  Nat. Med. 18, 624-629. (PubMed)

Maher, E.A., Marin-Valencia, I., Bachoo, R.M., Mashimo, T., Raisanen, J., Hatanpaa, K.J., Jindal, A., Choi, C., Jeffrey, F.M., Madden, C., Mathews, D., Pascual, J.M., Mickey, B.E., Malloy, C.R., and DeBerardinis, R.J. (2012). Metabolism of [U-13C]glucose in Human Brain Tumors In Vivo. NMR in Biomedicine 25, 1234-1244. (PubMed)

2011

Cheng, T., Sudderth, J., Yang, C., Mullen, A.R., Jin, E.S., Matés, J.M., and DeBerardinis, R.J. (2011). Pyruvate carboxylase catalyzes an alternative metabolic strategy allowing tumor cells to escape glutamine dependence. Proc. Natl. Acad. Sci. U. S. A 108, 8674–8679 (PubMed)

Mullen, A.R., Wheaton, W.W., Jin, E.S., Chen, P.H., Sullivan, L.B., Cheng, T., Yang, Y., Linehan, W.M., Chandel, N.S., and DeBerardinis, R.J. (2011). Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385–388. (PubMed)

2009

Yang, C., Sudderth, J., Dang, T., Bachoo, R.G., McDonald, J.G., and DeBerardinis, R.J. (2009). Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.  Cancer Res. 69, 7986-7993. (PubMed)

2008

DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., and Thompson, C.B. (2008).  The biology of cancer: metabolic reprogramming that fuels growth and proliferation.  Cell Metab. 7,11-20. (PubMed)

2007

DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., and Thompson, C.B. (2007). Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U. S. A 104, 19345–19350. (PubMed)