Selected DeBerardinis Lab Publications


Faubert, B., Solmonson, A., and DeBerardinis, R.J. (2020). Metabolic reprogramming and cancer progression. Science. 368, eaaw5473. (Full Text)

DeBerardinis, R.J.(2020). Tumor Microenvironment, Metabolism, and Immunotherapy. N Engl J Med.  382, 869-871. (PubMed)

Tasdogan, A., Faubert, B., Ramesh, V., Ubellacker, J.M., Shen, B., Solmonson, A., Murphy, M.M., Gu, Z., Gu, W., Martin, M., Kasitinon, S.Y., Vandergriff, T., Mathews, T.P., Zhao, Z., Schadendorf, D., DeBerardinis, R.J., and Morrison S,J. (2020). Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature 577,115-120. (PubMed)


Chen, P.H., Cai, L., Huffman, K., Yang, C., Kim, J., Faubert, B., Boroughs, L., Ko, B., Sudderth, J., McMillan, E.A., Girard, L., Chen, D., Peyton, M., Shields, M.D., Yao, B., Shames, D.S., Kim, H.S., Timmons, B., Sekine, I., Britt, R., Weber, S., Byers, L.A., Heymach, J.V., Chen, J., White, M.A., Minna, J.D., Xiao, G., and DeBerardinis, R.J. (2019). Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell.76, 838-851. (PubMed)

Ni, M., Solmonson, A., Pan, C., Yang, C., Li, D., Notzon, A., Cai, L., Guevara, G., Zacharias, L.G., Faubert, B., Vu, H.S., Jiang, L., Ko, B., Morales, N.M., Pei, J., Vale, G., Rakheja, D., Grishin, N.V., McDonald, J.G., Gotway, G.K., McNutt, M.C., Pascual, J.M., and DeBerardinis, R.J. (2019) Functional Assessment of Lipoyltransferase- Deficiency in Cells, Mice, and Humans. Cell Rep. 27, 1376-1386. (PubMed)


Shi, X., Tasdogan, A., Huang, F., Hu, Z., Morrison, S.J., and DeBerardinis, R.J. (2017). The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts. Sci Adv. 3, eaao5268. (PubMed)

Cai, L., Li, Q., Du, Y., Yun, J., Xie, Y., DeBerardinis, R.J., and Xiao, G. (2017). Genomic regression analysis of coordinated expression. Nat Commun. 8, 2187. (PubMed)

Jiang, L., Boufersaoui, A., Yang, C., Ko, B., Rakheja, D., Guevara, G., Hu, Z., and DeBerardinis, R.J. (2017). Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein. Metab Eng. 43, 198-207. (PubMed)

Courtney, K.D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy,V., Funk, A.M., Wimberly, J., McNeil, S.S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J.A., Pedrosa, I., DeBerardinis, R.J., Malloy, C.R., Bachoo, R.M., and Maher, E.A. (2018). Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. Cell Metab. 28, 793-800. (PubMed)

Huang, F., Ni, M., Chalishazar, M.D., Huffman, K.E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L.G., Ireland, A.S., Li, K., Gu, W., Kaushik, A.K., Liu, X., Gazdar, A.F., Oliver, T.G., Minna, J.D., Hu, Z., and DeBerardinis, R.J. (2018). Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Cell Metab. 28, 369-382. (PubMed)


Faubert, B., Li, K.Y., Cai, L., Hensley, C.T., Kim, J., Zacharias, L.G., Yang, C., Do, Q.N., Doucette, S., Burguete, D., Li, H., Huet, G., Yuan, Q., Wigal, T., Butt, Y., Ni, M., Torrealba, J., Oliver, D., Lenkinski, R.E., Malloy, C.R., Wachsmann, J.W, Young, J.D., Kernstine, K., and DeBerardinis, R.J. (2017) Lactate Metabolism in Human Lung Tumors. Cell 171, 358-371. (PubMed)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y-F., Ni, M., Huffman, K.E., Girard, L., Byers, L.A., Unsal-Kacmaz, K., Peña, C.G., Heymach, J.V., Wauters, E., Vansteenkiste, J., Castrillon, D.H., Chen, B.P.C., Wistuba, I,, Lambrechts, D., Xu, J., Minna, J.D., and DeBerardinis, R.J. (2017). CPS1 maintains pyrimidine pools and DNA synthesis is KRAS/LKB1-mutant lung cancer cells.  Nature 546, 168-172. (PubMed)

Faubert, B., and DeBerardinis, R.J. (2017). Analyzing tumor metabolism in vivo. Ann Rev Cancer Biol 1, 99-117.

Vander Heiden, M.G., and DeBerardinis, R.J. (2017). Understanding the intersections between metabolism and cancer biology. Cell 168, 657-699. (PubMed)


Hensley, C.T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., Jiang, L., Ko, B., Skelton, R., Loudat, L., et al. (2016). Metabolic heterogeneity in human lung tumors. Cell 164, 681–694. (PubMed)

Jiang, L., Shestov, A.A., Swain, P., Yang, C., Parker, S.J., Wang, Q.A., Terada, L.S., Adams, N.D., McCabe, M.T., Pietrak, B., et al. (2016). Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature 532, 255–258. (PubMed)

DeBerardinis, R.J., and Chandel, N.S. (2016). Fundamentals of cancer metabolism. Sci. Adv 2:e1600200. (PubMed)


Boroughs, L.K., and DeBerardinis, R.J. (2015). Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol 17, 351–359. (PubMed)

Rajagopalan. K.N., Egnatchik, R.A., Calvaruso, M.A., Wasti, A.T., Padanad, M.S., Boroughs, L.K., Ko, B., Hensley, C.T., Acar, M., Hu, Z., Jiang, L., Pascual, J.M., Scaglioni, P.P., and DeBerardinis, R.J. (2015). Metabolic plasticity maintains proliferation in pyruvate dehydrogenase-deficient cells. Cancer Metab. 3:7. (PubMed)

Piskounova, E., Agathocleous, M., Hu, Z., Mann, S.E., Zhao, Z., Leitch, A.M., Johnson, T.M., DeBerardinis, R.J., and Morrison, S.J. (2015). Reversible metabolic changes in human melanoma cells enable distant metastasis. Nature 527, 186-191. 


Mullen, A.R., Hu, Z., Shi, X., Jiang, L., Boroughs, L.K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L.B., Linehan, W.M., et al. (2014). Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep 7, 169-1690. (PubMed)

Yang, C., Ko, B., Hensley, C.T., Jiang, L., Wasti, A.T., Kim, J., Sudderth, J., Calvaruso, M.A., Lumata, L., Mitsche, et al. (2014). Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol. Cell 56, 414–424. (PubMed)


Hamanaka, R.B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen ,A.R., Getsios, S., Gottardi, C.J., DeBerardinis, R.J., Lavker, R.M., and Chandel, N.S. (2013). Mitochondrial ROS regulate epidermal differentiation and hair follicle development. Sci. Signal. 6, 261 (PubMed)

Kim, H., Pecot, C.V., Kim, J., Larsen, J.E., Mendiratta, S., Seo, B.Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Zubovych, I., Wu, S., DeBrabander, J., Komurov, K., Posner, B.A., Brekken, R., Sood, A.K., DeBerardinis, R.J., Roth, M.G., Minna, J.D., and White, M.A.  (2013). Systematic Identification of Molecular Subtype-selective Vulnerabilities in Non-Small Cell Lung Cancer.  Cell 155, 552-566. (PubMed)


DeBerardinis, R.J., and Thompson, C.B. (2012). Metabolism and disease: what metabolic outliers teach us about biology and pathology. Cell 148, 1132–1144. (PubMed)

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X. L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., et al. (2012). Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo. Cell Metab 15, 827–837. (PubMed)

Choi, C., Ganji, S.K., DeBerardinis, R.J., Hatanpaa, K.J., Rakheja, D., Kovacs, Z., Yang, X-L., Mashimo, T., Raisanen, J.M., et al. (2012). Noninvasive detection of 2-hydroxyglutarate by magnetic resonance spectroscopy in patients with IDH-mutated malignant gliomas.  Nat. Med. 18, 624-629. (PubMed)

Maher, E.A., Marin-Valencia, I., Bachoo, R.M., Mashimo, T., Raisanen, J., Hatanpaa, K.J., Jindal, A., Choi, C., Jeffrey, F.M., Madden, C., Mathews, D., Pascual, J.M., Mickey, B.E., Malloy, C.R., and DeBerardinis, R.J. (2012). Metabolism of [U-13C]glucose in Human Brain Tumors In Vivo. NMR in Biomedicine 25, 1234-1244. (PubMed)


Cheng, T., Sudderth, J., Yang, C., Mullen, A.R., Jin, E.S., Matés, J.M., and DeBerardinis, R.J. (2011). Pyruvate carboxylase catalyzes an alternative metabolic strategy allowing tumor cells to escape glutamine dependence. Proc. Natl. Acad. Sci. U. S. A 108, 8674–8679 (PubMed)

Mullen, A.R., Wheaton, W.W., Jin, E.S., Chen, P.H., Sullivan, L.B., Cheng, T., Yang, Y., Linehan, W.M., Chandel, N.S., and DeBerardinis, R.J. (2011). Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 481, 385–388. (PubMed)


Yang, C., Sudderth, J., Dang, T., Bachoo, R.G., McDonald, J.G., and DeBerardinis, R.J. (2009). Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.  Cancer Res. 69, 7986-7993. (PubMed)


DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., and Thompson, C.B. (2008).  The biology of cancer: metabolic reprogramming that fuels growth and proliferation.  Cell Metab. 7,11-20. (PubMed)


DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., and Thompson, C.B. (2007). Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U. S. A 104, 19345–19350. (PubMed)