Selected Zhu Lab Publications


Wei, Y., Wang, Y.G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., Lin, Y.H., Hsieh, M.H., Albrecht, J.H., Le, P.T., Rosen, C.J., Wang, T., and Zhu, H. (2021). Liver homeostasis is maintained by midlobular zone 2 hepatocytes. Science. 371:eabb1625. (PubMed)


Wang, Z., Chen, K., Jia, Y., Chuang, J.C., Sun, X., Lin, Y.H., Celen, C., Li, L., Huang, F., Liu, X., Castrillon, D.H., Wang, T., and Zhu, H. (2020). Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of residual complexes. Nature Cancer. 1, 909–922. (PubMed)

Lin, Y.H., Zhang, S., Zhu, M., Lu, T., Chen, K., Wen, Z., Wang, S., Xiao, G., Luo, D., Jia, Y., Li, L., MacConmara, M., Hoshida, Y., Singal, A., Yopp, A., Wang, T., and Zhu, H. (2020). Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity but Develop Fewer Tumors Following Chronic Liver Injury. Gastroenterology. 158, 1698-1712. (PubMed

Zhu,.M., Li, L., Lu, T., Yoo, H., Zhu, J., Gopal, P., Wang, S.C., Porempka, M.R., Rich, N.E., Kagan, S., Odewole, M., Renteria, V., Waljee, A.K., Wang, T., Singal, A.G., Yopp, A.C., and Zhu, H. (2020). Uncovering biological factors that regulate hepatocellular carcinoma growth using patient derived xenograft assays. Hepatology. Epub ahead of print. (PubMed


Zhu, M., Lu, T., Jia, Y., Luo, X., Gopal, P., Li, L., Odewole, M., Renteria, V., Singal, A.G., Jang, Y., Ge, K., Wang, S.C., Sorouri, M., Parekh, J.R., MacConmara, M.P., Yopp, A.C., Wang, T., and Zhu, H. (2019). Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 177, 1-14. (PubMed)


Moore, A., Wu, L., Chuang, J.C., Sun, X., Luo, X., Gopal, P., Li, L., Celen, C., Zimmer, M., and Zhu, H. (2018) Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation. Hepatology. 61, 1931-1945 (PubMed)

Wang, S.C., Nassour, I., Xiao, S., Zhang, S., Luo, X., Lee, J., Li, L., Sun, X., Nguyen, L.H., Chuang, J.C., Peng, L., Daigle, S., Shen, J., and Zhu H. (2018). SWI/SNF component ARID1Arestrains pancreatic neoplasia formation. Gut. 68, 1259-1270.(PubMed)

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H.C., Sehgal, A., Nguyen, L.H., Zhang, Yu., Gopal, P., Tarlow, B., Siegwart, D.J., and Zhu, H. (2018). The polyploid state plays a tumor suppressive role in the liver.  Developmental Cell.  44, 447-459. (PubMed)


Zhang, S., Nguyen, L.H., Zhou, K., Tu, H.C., Sehgal, A., Nassour, I., Li, L., Gopal, P., Goodman, J.,  Singal, A.G., Yopp, A., Zhang, Y., Siegwart, D.J., and Zhu, H. (2017). Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration. Gastroenterology. (PubMed)

Sun, X.*, Wang, S.C.*, Luo, X., Jia, Y., Li, L., Gopal, P., Zhu, M., Nassour, I., Chuang, J.C., Maples, T., Celen, C., Nguyen, L.H., Wu, L., Fu, S., Li, W., Hui, L., Tian, F., Ji, Y., Zhang, S., Sorouri, M., Hwang, T.H., Letzig, L., James, L., Yopp, A., Singal, A., and Zhu, H.  (2017). Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer. Cancer Cell. 32, 574-589. (PubMed) *Equal contributors.

Celen, C., Chuang, J.C., Luo, X., Nijem, N., Walker, A.K., Chen, F., Zhang, S., Chung, A.S., Nguyen, L.H., Nassour, I., Budhipramono, A., Sun, X., Bok, L.A., McEntagart, M., Gevers, E.F., Birnbaum, S.G., Eisch, A.J., Powell, C.M., Ge, W.P., Santen, G.W., Chahrour, M., and Zhu, H. (2017). Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. eLife. e25730. (PubMed)


Sun, X., Chuang, J.C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L.H., Wang, S.C., Signer, R.A., Sorouri, M., Nassour, I., Liu, X., Xu, J., Wu, M., Zhao, Y., Kuo, Y.C., Wang, Z., Xing, C., and Zhu, H. (2016). Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Cell Stem Cell 18, 456–466. (PubMed)

Zhou, K.*, Nguyen, L.H.*, Miller, J.B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J.T., Zhu, H., and Siegwart, D.J. (2016). Modular degradable dendrimers enable small RNAs to extend survival in an aggressiveliver cancer model. Proc. Natl. Acad. Sci. U S A 113, 520–525. (PubMed) *Equal contributors


Wen, X., Reynolds, L., Mulik, R.S., Kim, S.Y., Van Treuren, T., Nguyen, L.H., Zhu, H., and Corbin, I.R. (2016). Hepatic arterial infusion of low-density lipoprotein docosahexaenoic acid nanoparticles selectively disrupts redox balance in hepatoma cells and reduces growth of orthotopic liver tumors in rats. Gastroenterology 150, 488–498. (PubMed)

Wu, L.*, Nguyen, L.H.*, Zhou, K., Soysa, T.Y., Li, L., Miller, J.B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M.T., Zeitels, L.R., Acharya, A., Wang, S.C., Mendell, J.T., He, X., Nishino, J., Morrison, S.J., Siegwart, D.J., Daley, G.Q., Shyh-Chang, N., and Zhu, H. (2015). Precise Let-7 expression levels balance organ regeneration against tumor suppression. eLife. 4:e09431. (PubMed) *Equal contributors


Nguyen, L.H.*, Robinton, D.A.*, Seligson, M.T.*, Wu, L., Li, L., Rakheja, D., Comerford, S.A., Ramezani, S., Sun, X., Parikh, M.S., Yang, E.H., Powers, J.T., Shinoda, G., Shah, S.P., Hammer, R.E., Daley, G.Q.,** and Zhu, H.**. * (2014). Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell 26, 248–261. (PubMed) Equal contributors **Co-corresponding authors

Zhang, S.*, Li, L.*, Kendrick, S.L., Gerard, R.D., and Zhu, H.  (2014). TALEN mediated somatic mutagenesis in murine models of cancer. Cancer Res 74, 5311-5321. (PubMed) *Equal contributors

Urbach, A., Yermalovich, A., Zhang, J., Spina, C.S., Zhu, H., Perez-Atayde, A.R., Shukrun, R., Charlton, J., Sebire, N., Mifsud, W., Dekel, B., Pritchard-Jones, K., and Daley, G.Q. (2014). Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 28, 971–982. (PubMed)


Shyh-Chang, N.*, Zhu, H.*, de Soysa, N.T., Shinoda, G., Seligson, M.T., Tsanov, K., Nguyen, L., Asara, J.M., Cantley, L.C. and Daley, G.Q. (2013). Lin28 enhances tissue repair by reprogramming bioenergetic metabolism. Cell 155, 778–792. (PubMed) *Equal contributors

Nishino, J., Kim, S., Zhu, Y., Zhu, H., and Morrison, S.J. (2013). A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. eLife 2:e00924. (PubMed)

Shyh-Chang, N., Locasale, J.W., Lyssiotis, C.A., Zheng, Y., Teo, R.Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J.J., Zhu, H., Asara, J.M., Daley, G.Q., and Cantley, L.C. (2013). Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation. Science 339, 222–226. (PubMed)


Zhu, H.*, Shyh-Chang, N.*, et al.  (2011). The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell 147, 81–94. (PubMed) *Equal contributors

Zhu, H., Lensch, M.W., Cahan, P., Daley, G.Q. (2011). Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. Genet 12, 266–275. (PubMed)

Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., et al. (2011). Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 470, 95–100. (PubMed)


Zhu, H., et al. (2010). Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat. Genet 42, 626–630. (PubMed)


West, J.A., Viswanathan, S.R., Yabuuchi, A., Cunniff, K., Takeuchi, A., Park, I.H., Sero, J.E., Zhu, H., et al. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460, 909–913. (PubMed)