In the News

September 2013

Sept. 23, 2013 — Children’s Medical Center Research Institute at UT Southwestern has recruited a new faculty member, Woo-Ping Ge, Ph.D. His laboratory will research the interactions between brain vasculature and the nervous system, in hopes of developing therapeutic targets for treating diseases such as stroke and brain tumors. Dr. Ge recently shared his thoughts about joining the CRI team and the impact he expects his new surroundings will have on his work. Read the Q&A interview.

Sept. 19, 2013 — Previously published research has suggested that the properties of cancer stem cells can explain a variety of unsolved clinical problems. However, new experimental approaches have provided additional perspective and insight regarding the extent to which metastasis, therapy resistance and disease progression reflect the intrinsic properties of cancer stem cells as opposed to genetic evolution or other sources of variation in cancer cell properties.

Sean Morrison, Ph.D., Director of the Children’s Research Institute at UT Southwestern (CRI), and Corbin Meacham, Ph.D., an American Cancer Society Fellow at CRI, have evaluated the implications of new data for the cancer stem-cell model and the degree to which the model accounts for clinically important aspects of disease progression, like therapy resistance and metastatic dissemination. Read their research review published in Nature.

Sept. 3, 2013 — Glutamine is an abundant and highly versatile nutrient whose metabolism has implications for tumor cell biology, making it an appealing target for new clinical strategies to detect, monitor and treat cancer. Ralph DeBerardinis, M.D., Ph.D., Director of the Genetic and Metabolic Disease Program at the Children’s Research Institute at UT Southwestern (CRI); Ajla Wasti, M.D., a clinical fellow at CRI; and Chris Hensley, an M.D./Ph.D. student at CRI, have evaluated the metabolic functions of glutamine and its involvement in supporting tumor malignancy, in an effort to better understand how the information could be used in clinical oncology. Read their research review published in The Journal of Clinical Investigation.