Research News Electron transport chain inhibition increases cellular dependence on purine transport, salvage All Research News >
Research News Electron transport chain inhibition increases cellular dependence on purine transport, salvage All Research News >
Metabolism, Regenerative Medicine June 13, 2024 Metabolic inflexibility keeps damage at bay during liver regeneration Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver…
June 3, 2024 Meet Dr. Regina Shin Hijai (Regina) Shin, Ph.D., is the newest CRI faculty member, launching the Shin Lab in…
July 11, 2024 Tumor growth fueled by nucleotide salvage Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage pathway in … Cancer Biology, Metabolism
June 19, 2024 PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer Summary: Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness, however, … Regenerative Medicine
June 13, 2024 Metabolic inflexibility keeps damage at bay during liver regeneration Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver cells have … Metabolism, Regenerative Medicine
June 13, 2024 Electron transport chain inhibition increases cellular dependence on purine transport, salvage Scientists have identified a new way to disrupt lung cancer growth in research from Children’s Medical … Metabolism
May 1, 2024 Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after … Cancer Biology
August 23, 2023 Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic resonance (NMR) … Metabolism
May 5, 2023 The metabolism of neutrophils and its contribution to severe COVID-19 Metabolic changes in neutrophils, the most abundant type of white blood cell, may contribute to severe …
April 12, 2023 The presence of extrachromosomal DNA can accelerate cancer formation Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, … Cancer Biology
April 10, 2023 Mutant clones in the liver may fight fatty liver disease Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether these mutations are adaptive … Regenerative Medicine
January 11, 2023 Lactate metabolism plays an important role in mitochondrial diseases Lactate, long considered to be a waste product of energy production, has been found to fuel … Metabolism
December 14, 2022 Scientists identify a molecular switch that speeds up muscle repair Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened thanks to … Metabolism
November 29, 2022 New research challenges long-standing assumption of how liver cells produce energy Within our cells, mitochondria are responsible for converting food into energy. This works by taking electrons …