News

July 16, 2026

New biosensor tracks down missing metabolite from childhood brain disorder

Science study shows alpha-ketoglutarate supplementation may delay progression of GPT2 deficiency, rare inborn error of metabolism …

Metabolism

June 24, 2026

Mechanisms for ecDNA survival during cell division uncovered

Targeting transcription machinery could disturb ecDNA maintenance, reduce oncogenicity Dallas – June 24, 2026 – Extrachromosomal …

Cancer Biology

May 19, 2026

Human cells can exchange genomic DNA that alters cell behavior

Children’s Research Institute scientists discover that DNA transferred between cells can be inherited, remain biologically active …

Cancer Biology

April 29, 2026

Cell maturity determines pyrimidine synthesis pathway preference

McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification of enzyme …

Metabolism

December 23, 2025

Loss of vitamin C synthesis protects animals from schistosomiasis

Agathocleous Lab, collaborators discover vitamin C deficiency can benefit animals by depriving vitamin from parasitic worms …

November 6, 2025

Location matters for liver cancer’s origins

Hepatocellular carcinoma arises primarily in zone 3 due to glutathione transferase genes that help mutated cells …

Cancer Biology, Regenerative Medicine

November 6, 2025

Protein regulating balance between purine nucleotide production pathways discovered

NUDT5 suppresses de novo purine biosynthesis through PPAT interaction, affects thiopurine sensitivity The protein NUDT5 is …

Metabolism

July 30, 2025

PEX39 discovered: first human peroxin in 20 years

CRI researchers, international colleagues identify PEX39, which facilitates peroxisomal protein import PEX39 is the first new …

Metabolism

June 11, 2025

Unique pathway tumors use to acquire antioxidant lipids uncovered

CRI researchers find cancer cells use sulfated glycosaminoglycans to draw in lipoproteins, gain antioxidant protection from …

Cancer Biology

April 29, 2025

Mitochondria use NADPH to fuel fatty acid synthesis, lipoylation

Mitochondrial NADPH — a metabolite and essential electron donor — drives mitochondrial fatty acid synthesis (mtFAS) …

Metabolism

March 12, 2025

DeBerardinis, Zhang find crucial metabolic pathway targeted by drug creates key vulnerability in cancer cells

Metabolism

February 19, 2025

High glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

DALLAS – Feb. 19, 2025 – In localized non-small cell lung cancer (NSCLC), a tumor’s ability …

Cancer Biology, Metabolism

Category

New biosensor tracks down missing metabolite from childhood brain disorder

Mechanisms for ecDNA survival during cell division uncovered

Human cells can exchange genomic DNA that alters cell behavior

Cell maturity determines pyrimidine synthesis pathway preference

Loss of vitamin C synthesis protects animals from schistosomiasis

Location matters for liver cancer’s origins

Protein regulating balance between purine nucleotide production pathways discovered

PEX39 discovered: first human peroxin in 20 years

Unique pathway tumors use to acquire antioxidant lipids uncovered

Mitochondria use NADPH to fuel fatty acid synthesis, lipoylation

DeBerardinis, Zhang find crucial metabolic pathway targeted by drug creates key vulnerability in cancer cells

High glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

Inside CRI Newsletter