Ge Laboratory

woo-ping

Assistant Professor, Pediatrics

Assistant Professor, Neuroscience

Curriculum Vitae

An adult human brain accounts for 2% of total body weight but consumes approximately 20% of the body’s energy. Interactions between the brain vasculature (i.e., blood vessels), glial cells and neurons are critical for brain metabolism.

The long-term goal of our lab is to understand the mechanisms underlying the interactions between the brain vasculature and the nervous system (Fig. 1 and 2). Combining electrophysiology and in vivo imaging with genetic methods, our lab studies: (1) how a brain builds the gliovascular and neurovascular network during development; (2) how this network is damaged during strokes; and (3) how the network is repaired after strokes. Ultimately, this focus might lead to the development of novel therapeutic targets for treating stroke, which affects about 700,000 Americans each year.

Fig. 1. Brain vasculature.
Ge Lab Research - Brain Vasculature
Brain vasculature transports oxygen, glucose and other important substances to the brain to ensure its proper functioning. Dysfunction of brain vasculature is closely related to many diseases including stroke and migraine. Click image to enlarge.

 

Fig. 2. Glia-vasculature-neuron network.
ge-lab-figure2
Astrocytes are the largest population of glial cells. Their processes, called endfeet, completely cover the abluminal vascular surface in the adult brain. Endothelial cells and pericytes form capillaries, the smallest of the blood vessels serving as the connection between the arterial and venous systems. Click image to enlarge.