Researchers are just now beginning to appreciate the ways in which differences in protein synthesis among mammalian somatic cells are necessary for tissue development and homeostasis, as new approaches are making it possible to more generally compare protein synthesis and its regulation among different kinds of cells.
Dr. Sean Morrison, Director of the Children’s Medical Center Research Institute at UT Southwestern, is senior author of a review of research that focuses on differences in protein synthesis, protein stability, and ribosome assembly among cells that are critical for tissue development and homeostasis.
The mechanisms that underlie these differences are only beginning to be clarified, but they are already providing fundamental new insights into development, tissue regeneration, and how these processes go wrong in degenerative diseases and cancer.
Read the research review published in Cell.
