UT Southwestern Medical Center scientists have developed an innovative model for predicting the progression of skin cancer in patients.
For a study published this week in Science Translational Medicine, Stage III human melanoma cells from 20 patients were implanted into specially selected mice with compromised immune systems. Children’s Medical Center Research Institute researchers were able to observe differences in the rate at which the cancer spread, or metastasized, in the mice that correlated with clinical outcomes in patients. They used a xenograft model, in which tissue is transplanted from one species to another.
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