Mouse Genome Engineering Core

About

The CRI Mouse Genome Engineering Core Facility is committed to helping researchers produce mouse models to support fundamental and translational research, providing transgenic, gene targeting and other services. Established in 2014, the facility serves scientists at CRI, UT Southwestern and other institutes.

Our core services include:

  • CRISPR/Cas9 microinjection
  • Random transgenesis
  • Embryonic stem (ES) cell gene targeting
  • Colony management – Sperm and embryo cryopreservation
  • Strain rederivation – IVF and ICSI
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Process

SERVICES

We offer end-to-end services for generation of genetically modified founder mice. As well as a variety of cost-effective colony management solutions.

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CONSULTATION

Due to the complex nature of most transgenic experiments, we recommend that all involved parties discuss the details of the project and the experimental plan with facility personnel before the initiation of any new project.

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PROJECT REQUEST

To request Core services, please logon into PPMS, and order the desired service.

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By the Numbers

Projects Completed

143

Labs Serviced

28

Our Team

Hao Zhu, M.D.

Scientific Director of the Facility

Nicolas Loof, M.S.

CRI Facilities Manager

Tripti Sharma, Ph.D.

Core Research Scientist

Yu Zhang, Ph.D.

Core Research Scientist