Mouse Genome Engineering Core


The CRI Mouse Genome Engineering Core Facility is committed to helping researchers produce mouse models to support fundamental and translational research, providing transgenic, gene targeting and other services. Established in 2014, the facility serves scientists at CRI, UT Southwestern and other institutes.

Our core services include:

  • CRISPR/Cas9 microinjection
  • Random transgenesis
  • Embryonic stem (ES) cell gene targeting
  • Colony management – Sperm and embryo cryopreservation
  • Strain rederivation – IVF and ICSI
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mouse genome engineering



We offer end-to-end services for generation of genetically modified founder mice. As well as a variety of cost-effective colony management solutions.

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Due to the complex nature of most transgenic experiments, we recommend that all involved parties discuss the details of the project and the experimental plan with facility personnel before the initiation of any new project.

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To request Core services, please logon into PPMS, and order the desired service.

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By the Numbers

Projects Completed


Labs Serviced


Our Team

Hao Zhu, mouse genome engineering

Hao Zhu, M.D.

Scientific Director of the Facility

Suman Komjeti, B.S.

Senior Research Associate

Tripti Sharma, mouse genome engineering

Tripti Sharma, Ph.D.

Core Research Scientist

Yu Zhang, mouse genome engineering

Yu Zhang, B.S.

Core Research Scientist