The CRI Mouse Genome Engineering Core Facility is committed to helping researchers produce mouse models to support fundamental and translational research, providing transgenic, gene targeting and other services. Established in 2014, the facility serves scientists at CRI, UT Southwestern and other institutes. We offer cutting edge CRISPR/Cas9 services for direct production of mutant mice by pronuclear injection along with random transgenesis using classical genetic engineering techniques.
Our core services include:
- CRISPR/Cas9 microinjection
- Random transgenesis
- Embryonic stem (ES) cell gene targeting
- Colony management – Sperm and embryo cryopreservation
- Strain rederivation – IVF and ICSI
We offer end-to-end services for generation of genetically modified founder mice. As well as a variety of cost-effective colony management solutions.