News

November 1, 2024

Mishra Lab discovers mitochondrial DNA mutations prevent metastasis in skin cancers

Research builds on prior CRI discovery about healthy mitochondrial metabolism being necessary for cancer spread Human …

Metabolism

October 24, 2024

Morrison Lab discovers ancient viral DNA activates blood cell production during pregnancy, after bleeding

Study published in Science shows humans co-opted retrotransposons to avoid anemia during pregnancy DALLAS – Oct. …

Regenerative Medicine

August 14, 2024

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers from more …

Cancer Biology, Metabolism

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage pathway in …

Cancer Biology, Metabolism

June 19, 2024

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Summary: Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness, however, …

Regenerative Medicine

June 13, 2024

Metabolic inflexibility keeps damage at bay during liver regeneration

Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver cells have …

Metabolism, Regenerative Medicine

June 13, 2024

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Scientists have identified a new way to disrupt lung cancer growth in research from Children’s Medical …

Metabolism

May 1, 2024

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after …

Cancer Biology

August 23, 2023

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic resonance (NMR) …

Metabolism

May 5, 2023

The metabolism of neutrophils and its contribution to severe COVID-19

Metabolic changes in neutrophils, the most abundant type of white blood cell, may contribute to severe …

April 12, 2023

The presence of extrachromosomal DNA can accelerate cancer formation

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, …

Cancer Biology

April 10, 2023

Mutant clones in the liver may fight fatty liver disease

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether these mutations are adaptive …

Regenerative Medicine

Zhu Lab shows location matters for liver cancer’s origins

DeBerardinis Lab discovers protein regulating balance between purine nucleotide production pathways

Garcia-Bermudez Lab uncovers unique pathway tumors use to acquire antioxidant lipids

Category

Mishra Lab discovers mitochondrial DNA mutations prevent metastasis in skin cancers

Morrison Lab discovers ancient viral DNA activates blood cell production during pregnancy, after bleeding

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

Tumor growth fueled by nucleotide salvage

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Metabolic inflexibility keeps damage at bay during liver regeneration

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

The metabolism of neutrophils and its contribution to severe COVID-19

The presence of extrachromosomal DNA can accelerate cancer formation

Mutant clones in the liver may fight fatty liver disease

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