News

June 11, 2025

Garcia-Bermudez Lab uncovers unique pathway tumors use to acquire antioxidant lipids

CRI researchers find cancer cells use sulfated glycosaminoglycans to draw in lipoproteins, gain antioxidant protection from …

Cancer Biology

April 15, 2025

Hijai Regina Shin, Ph.D., named 2025 Searle Scholar

Newest investigator in Children’s Medical Center Research Institute at UT Southwestern recognized for innovative…

Cancer Biology, Metabolism

February 19, 2025

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

DALLAS – Feb. 19, 2025 – In localized non-small cell lung cancer (NSCLC), a…

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage pathway in …

Cancer Biology, Metabolism

June 19, 2024

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Summary: Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness, however, …

Regenerative Medicine

June 13, 2024

Metabolic inflexibility keeps damage at bay during liver regeneration

Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver cells have …

Metabolism, Regenerative Medicine

June 13, 2024

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Scientists have identified a new way to disrupt lung cancer growth in research from Children’s Medical …

Metabolism

May 1, 2024

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after …

Cancer Biology

August 23, 2023

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic resonance (NMR) …

Metabolism

May 5, 2023

The metabolism of neutrophils and its contribution to severe COVID-19

Metabolic changes in neutrophils, the most abundant type of white blood cell, may contribute to severe …

April 12, 2023

The presence of extrachromosomal DNA can accelerate cancer formation

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, …

Cancer Biology

April 10, 2023

Mutant clones in the liver may fight fatty liver disease

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether these mutations are adaptive …

Regenerative Medicine

January 11, 2023

Lactate metabolism plays an important role in mitochondrial diseases

Lactate, long considered to be a waste product of energy production, has been found to fuel …

Metabolism

December 14, 2022

Scientists identify a molecular switch that speeds up muscle repair

Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened thanks to …

Metabolism

November 29, 2022

New research challenges long-standing assumption of how liver cells produce energy

Within our cells, mitochondria are responsible for converting food into energy. This works by taking electrons …

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News

Garcia-Bermudez Lab uncovers unique pathway tumors use to acquire antioxidant lipids

Hijai Regina Shin, Ph.D., named 2025 Searle Scholar

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

Category

Tumor growth fueled by nucleotide salvage

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Metabolic inflexibility keeps damage at bay during liver regeneration

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

The metabolism of neutrophils and its contribution to severe COVID-19

The presence of extrachromosomal DNA can accelerate cancer formation

Mutant clones in the liver may fight fatty liver disease

Lactate metabolism plays an important role in mitochondrial diseases

Scientists identify a molecular switch that speeds up muscle repair

New research challenges long-standing assumption of how liver cells produce energy

Inside CRI Newsletter

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