Cancer Biology Archives - Children's Medical Center Research Institute (CRI)

Cancer Biology, Metabolism

August 14, 2024

Kidney cancers rely on mitochondrial metabolism to metastasize

DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers…

Cancer Biology, Metabolism

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage…

Cancer Biology

May 1, 2024

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires…

Cancer Biology

April 12, 2023

The presence of extrachromosomal DNA can accelerate cancer formation

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance…

Cancer Biology

October 12, 2022

Scientists discover a new mechanism for therapy resistance in acute leukemias

New research has uncovered a previously unknown mechanism that explains why patients with acute…

Cancer Biology, Genetics

August 18, 2022

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Scientists in the McBrayer lab in Children’s Medical Center Research Institute at UT Southwestern…

Cancer Biology

April 8, 2021

Scientists discover “jumping” genes that can protect against blood cancers

New research has uncovered a surprising role for so-called “jumping” genes that are a…

Cancer Biology

August 19, 2020

Lymph protects metastasizing melanoma cells from ferroptosis

For decades, physicians have known that many kinds of cancer cells often spread first…

Cancer Biology

December 18, 2019

CRI scientists discover metabolic feature that allows melanoma cells to spread

Researchers at Children’s Medical Center Research Institute at UT Southwestern (CRI) have uncovered why…

Research Area: Cancer Biology

CRI awarded nearly $7M in research grants from CPRIT

Kidney cancers rely on mitochondrial metabolism to metastasize

Tumor growth fueled by nucleotide salvage

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

The presence of extrachromosomal DNA can accelerate cancer formation

Scientists discover a new mechanism for therapy resistance in acute leukemias

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Scientists discover “jumping” genes that can protect against blood cancers

Lymph protects metastasizing melanoma cells from ferroptosis

CRI scientists discover metabolic feature that allows melanoma cells to spread

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