Discovery Archive - Children's Medical Center Research Institute (CRI)

Metabolism, Regenerative Medicine

June 13, 2024

Metabolic inflexibility ensures only healthy liver cells regenerate

Researchers have identified a type of metabolic inflexibility during liver regeneration that prevents cells…

Cancer Biology

May 1, 2024

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires…

Cancer Biology

April 12, 2023

The presence of extrachromosomal DNA can accelerate cancer formation

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance…

Regenerative Medicine

April 10, 2023

Mutant clones in the liver may fight fatty liver disease

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether these mutations…

Metabolism

January 11, 2023

Lactate metabolism plays an important role in mitochondrial diseases

Lactate, long considered to be a waste product of energy production, has been found…

Metabolism

December 14, 2022

Scientists identify a molecular switch that speeds up muscle repair

Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened…

Regenerative Medicine

October 21, 2022

Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different…

Cancer Biology

October 12, 2022

Scientists discover a new mechanism for therapy resistance in acute leukemias

New research has uncovered a previously unknown mechanism that explains why patients with acute…

Cancer Biology, Genetics

August 18, 2022

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Scientists in the McBrayer lab in Children’s Medical Center Research Institute at UT Southwestern…

Regenerative Medicine

May 22, 2022

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

How are haematopoietic stem cells (HSCs) protected from inflammation, which increases with age and…

More Discoveries

Metabolic inflexibility ensures only healthy liver cells regenerate

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

The presence of extrachromosomal DNA can accelerate cancer formation

Mutant clones in the liver may fight fatty liver disease

Lactate metabolism plays an important role in mitochondrial diseases

Scientists identify a molecular switch that speeds up muscle repair

Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

Scientists discover a new mechanism for therapy resistance in acute leukemias

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

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