Discovery Archive - Children's Medical Center Research Institute (CRI)

Cancer Biology

October 12, 2022

Scientists discover a new mechanism for therapy resistance in acute leukemias

New research has uncovered a previously unknown mechanism that explains why patients with acute…

Cancer Biology, Genetics

August 18, 2022

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Scientists in the McBrayer lab in Children’s Medical Center Research Institute at UT Southwestern…

Regenerative Medicine

May 22, 2022

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

How are haematopoietic stem cells (HSCs) protected from inflammation, which increases with age and…

Metabolism

April 6, 2022

Researchers uncover unique metabolic needs during pregnancy

Researchers in the DeBerardinis lab in CRI developed a new method to study metabolism…

Regenerative Medicine

February 16, 2022

New research finds muscle tissues absorb damaged stem cells

As we age, our muscle stem cells accumulate mitochondrial mutations that undermine the function…

Metabolism

April 8, 2021

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of…

Cancer Biology

April 8, 2021

Scientists discover “jumping” genes that can protect against blood cancers

New research has uncovered a surprising role for so-called “jumping” genes that are a…

Regenerative Medicine

February 25, 2021

Scientists identify cells responsible for liver tissue maintenance and regeneration

While the amazing regenerative power of the liver has been known since ancient times,…

Regenerative Medicine

February 24, 2021

Researchers identify mechanism by which exercise strengthens bones and immunity

Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified…

Cancer Biology

August 19, 2020

Lymph protects metastasizing melanoma cells from ferroptosis

For decades, physicians have known that many kinds of cancer cells often spread first…

More Discoveries

Scientists discover a new mechanism for therapy resistance in acute leukemias

Researchers identify new druggable therapeutic pathway in a deadly form of brain cancer

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

Researchers uncover unique metabolic needs during pregnancy

New research finds muscle tissues absorb damaged stem cells

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

Scientists discover “jumping” genes that can protect against blood cancers

Scientists identify cells responsible for liver tissue maintenance and regeneration

Researchers identify mechanism by which exercise strengthens bones and immunity

Lymph protects metastasizing melanoma cells from ferroptosis

About

Research

Shared Facilities

Training

News