Discovery Archive - Children's Medical Center Research Institute (CRI)

Regenerative Medicine

October 24, 2024

Morrison Lab discovers ancient viral DNA activates blood cell production during pregnancy, after bleeding

Study published in Science shows humans co-opted retrotransposons to avoid anemia during pregnancy DALLAS…

Cancer Biology, Metabolism

August 14, 2024

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers…

Cancer Biology, Metabolism

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage…

Metabolism, Regenerative Medicine

June 13, 2024

Metabolic inflexibility keeps damage at bay during liver regeneration

Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver…

Cancer Biology

May 1, 2024

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

Summary: Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires…

Cancer Biology

April 12, 2023

The presence of extrachromosomal DNA can accelerate cancer formation

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance…

Regenerative Medicine

April 10, 2023

Mutant clones in the liver may fight fatty liver disease

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether these mutations…

Metabolism

January 11, 2023

Lactate metabolism plays an important role in mitochondrial diseases

Lactate, long considered to be a waste product of energy production, has been found…

Metabolism

December 14, 2022

Scientists identify a molecular switch that speeds up muscle repair

Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened…

Regenerative Medicine

October 21, 2022

Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) found that different…

More Discoveries

Morrison Lab discovers ancient viral DNA activates blood cell production during pregnancy, after bleeding

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

Tumor growth fueled by nucleotide salvage

Metabolic inflexibility keeps damage at bay during liver regeneration

Small cell lung cancer acquires cross-resistance due to extrachromosomal DNA amplification of MYC paralogs

The presence of extrachromosomal DNA can accelerate cancer formation

Mutant clones in the liver may fight fatty liver disease

Lactate metabolism plays an important role in mitochondrial diseases

Scientists identify a molecular switch that speeds up muscle repair

Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

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