Discovery Archive - Children's Medical Center Research Institute (CRI)

Cancer Biology, Metabolism

February 19, 2025

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

DALLAS – Feb. 19, 2025 – In localized non-small cell lung cancer (NSCLC), a…

Cancer Biology, Metabolism

August 14, 2024

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers…

Cancer Biology, Metabolism

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage…

Metabolism, Regenerative Medicine

June 13, 2024

Metabolic inflexibility keeps damage at bay during liver regeneration

Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver…

Metabolism

January 11, 2023

Lactate metabolism plays an important role in mitochondrial diseases

Lactate, long considered to be a waste product of energy production, has been found…

Metabolism

December 14, 2022

Scientists identify a molecular switch that speeds up muscle repair

Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened…

Metabolism

April 6, 2022

Researchers uncover unique metabolic needs during pregnancy

Researchers in the DeBerardinis lab in CRI developed a new method to study metabolism…

Metabolism

April 8, 2021

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of…

Genetics, Metabolism

April 30, 2019

New screening approach helps identify sources of rare genetic diseases in children

Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) are using…

Metabolism

June 28, 2018

Researchers discover new vulnerability in small cell lung cancer

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered…

More Discoveries

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

Tumor growth fueled by nucleotide salvage

Metabolic inflexibility keeps damage at bay during liver regeneration

Lactate metabolism plays an important role in mitochondrial diseases

Scientists identify a molecular switch that speeds up muscle repair

Researchers uncover unique metabolic needs during pregnancy

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

New screening approach helps identify sources of rare genetic diseases in children

Researchers discover new vulnerability in small cell lung cancer

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