Key Discovery New biosensor tracks down missing metabolite from childhood brain disorder All Discoveries >
Key Discovery New biosensor tracks down missing metabolite from childhood brain disorder All Discoveries >
Metabolism July 16, 2026 New biosensor tracks down missing metabolite from childhood brain disorder Science study shows alpha-ketoglutarate supplementation may delay progression of GPT2 deficiency, rare inborn error…
Metabolism April 29, 2026 Cell maturity determines pyrimidine synthesis pathway preference McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification…
Metabolism November 6, 2025 Protein regulating balance between purine nucleotide production pathways discovered NUDT5 suppresses de novo purine biosynthesis through PPAT interaction, affects thiopurine sensitivity The protein…
Metabolism July 30, 2025 PEX39 discovered: first human peroxin in 20 years CRI researchers, international colleagues identify PEX39, which facilitates peroxisomal protein import PEX39 is the…
Metabolism April 29, 2025 Mitochondria use NADPH to fuel fatty acid synthesis, lipoylation Mitochondrial NADPH — a metabolite and essential electron donor — drives mitochondrial fatty acid…
Metabolism March 12, 2025 DeBerardinis, Zhang find crucial metabolic pathway targeted by drug creates key vulnerability in cancer cells
Cancer Biology, Metabolism February 19, 2025 High glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread DALLAS – Feb. 19, 2025 – In localized non-small cell lung cancer (NSCLC), a…
Metabolism November 1, 2024 Mitochondrial DNA mutations prevent metastasis in skin cancers Research builds on prior CRI discovery about healthy mitochondrial metabolism being necessary for cancer…
Cancer Biology, Metabolism August 14, 2024 Kidney cancers rely on mitochondrial metabolism to metastasize DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers…
Cancer Biology, Metabolism July 11, 2024 Tumor growth fueled by nucleotide salvage Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage…
