Metabolism Archives - Children's Medical Center Research Institute (CRI)

Metabolism

April 29, 2025

Hoxhaj Lab discovers how mitochondria use NADPH to fuel fatty acid synthesis, lipoylation

Mitochondrial NADPH — a metabolite and essential electron donor — drives mitochondrial fatty acid…

Cancer Biology, Metabolism

February 19, 2025

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

DALLAS – Feb. 19, 2025 – In localized non-small cell lung cancer (NSCLC), a…

Metabolism

November 1, 2024

Mishra Lab discovers mitochondrial DNA mutations prevent metastasis in skin cancers

Research builds on prior CRI discovery about healthy mitochondrial metabolism being necessary for cancer…

Cancer Biology, Metabolism

August 14, 2024

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

DeBerardinis Lab researchers collaborated with UTSW surgeons to trace pathways used in kidney cancers…

Cancer Biology, Metabolism

July 11, 2024

Tumor growth fueled by nucleotide salvage

Hoxhaj Lab measures purine pathways across tissues and tumors, revealing crucial role of salvage…

Metabolism, Regenerative Medicine

June 13, 2024

Metabolic inflexibility keeps damage at bay during liver regeneration

Mishra Lab pinpoints PDK4 enzyme that starves cells with mitochondrial damage (NEWS RELEASE) Liver…

Metabolism

June 13, 2024

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Scientists have identified a new way to disrupt lung cancer growth in research from…

Metabolism

August 23, 2023

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic…

Metabolism

January 11, 2023

Lactate metabolism plays an important role in mitochondrial diseases

Lactate, long considered to be a waste product of energy production, has been found…

Metabolism

December 14, 2022

Scientists identify a molecular switch that speeds up muscle repair

Recovery time for muscle sprains, strains, and other soft tissue injuries could be shortened…

Research Area: Metabolism

Hoxhaj Lab discovers how mitochondria use NADPH to fuel fatty acid synthesis, lipoylation

DeBerardinis Lab finds high glucose contribution to tricarboxylic acid cycle involved in predicting cancer spread

Mishra Lab discovers mitochondrial DNA mutations prevent metastasis in skin cancers

DeBerardinis Lab discovers kidney cancers rely on mitochondrial metabolism to metastasize

Tumor growth fueled by nucleotide salvage

Metabolic inflexibility keeps damage at bay during liver regeneration

Electron transport chain inhibition increases cellular dependence on purine transport, salvage

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

Lactate metabolism plays an important role in mitochondrial diseases

Scientists identify a molecular switch that speeds up muscle repair

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