By addressing fundamental scientific questions, CRI is improving our understanding of the biological basis of disease and making discoveries that have the potential to improve the treatment of diseases and help to cure somebody who would not be cured otherwise.

OUR DISCOVERIES


Discovery timeline dates represent the month discoveries were published.

May 2011

CRI founded and Sean Morrison, Ph.D. recruited as director.
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January 2012

The environment in which blood-forming stem cells are maintained within the bone marrow identified. This is an important step toward increasing the safety and effectiveness of bone-marrow transplantation.
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April 2012

Ralph DeBerardinis, M.D., Ph.D. joined CRI.
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June 2012

First measurements of energy-forming pathways discovered in living brain tumors in mice.
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September 2012

Hao Zhu, M.D. joined CRI.
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November 2012

Innovative experimental model for predicting the progression of skin cancer in patients discovered.
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February 2013

Environment where specialized blood-forming cells produce infection-fighting white blood cells (T cells and B cells) identified.
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July 2013

New markers found to distinguish biologically distinct subpopulations of stem cells and multipotent progenitors in the blood-forming system.
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August 2013

Formation of new blood vessels found to be directed by metabolism of glucose.
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September 2013

Genetic and Metabolic Disease Program launched to better understand the biological basis of childhood genetic diseases and to improve therapy options.
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September 2013

Woo-Ping Ge, Ph.D. joined CRI.
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October 2013

New therapeutic targets identified for patients with the common form of lung cancer among smokers, nonsmokers and people under age 45.
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November 2013

Network of RNA binding proteins turned on during fetal development discovered to promote stem cell self-renewal and tissue repair by regulating cellular proliferation and metabolism.
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November 2013

Early mutations that contribute to the development of leukemia found to act by changing the way blood-forming stem cells divide.
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January 2014

Estrogen found to be a prolific promoter of stem cell self-renewal in the blood-forming system.
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March 2014

Method of measuring protein synthesis in adult stem cells discovered.
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May 2014

Identification of biomarkers prove neurosphere-initiating cells are not neural stem cells, improving the ability of researchers to identify and study neural stem cells.
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May 2014

Identification of the triggering mechanism that causes a metabolic pathway called the Krebs cycle to run in reverse, allows certain cancer cells to grow.
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June 2014

Key biomarker needed for identification, characterization and enrichment of bone-forming stem cells discovered.
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July 2014

Development of new “gene edited” mouse models of liver cancer that improve our ability to study the disease.
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August 2014

Lin28b identified as a contributor to the development of childhood liver cancer and potential therapeutic target.
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September 2014

Jian Xu, Ph.D. joined CRI.
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November 2014

Identification of a new metabolic pathway that allows cancer cells to survive periods of energy stress.
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September 2015

CRI first to use a tissue-clearing technique to localize rare stem cells and to identify the location of blood-forming stem cells in the bone marrow
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October 2015

Let-7 microRNA found to antagonize liver cancer at the expense of efficient liver regeneration.
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October 2015

Antioxidants found to promote the spread of cancer cells.
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November 2015

Prashant Mishra, M.D., Ph.D. joined CRI.
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November 2015

Researchers identified a secondary, emergency blood-formation system in the spleen.
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January 2016

Researchers pioneered new methods to study how genes are turned on and off in blood-forming cells.
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February 2016

Human lung tumors discovered to use a variety of metabolic activities to survive; an innovative approach to study the processes that fuel tumor growth in patients identified.
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March 2016

Discovered that when an epigenetic regulator called Arid1a is suppressed, tissue regeneration is enhanced.
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March 2016

New mechanisms by which the diet influences the balance between the formation of fat and bone in the bone marrow discovered.
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April 2016

New metabolic pathway discovered to help cancer cells thrive under conditions lethal to normal cells.
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December 2016

New bone-forming growth factor that reverses osteoporosis in mice discovered.
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